ArticleAmerican journal of hypertension2009
Association of 25-hydroxyvitamin D with blood pressure in predominantly 25-hydroxyvitamin D deficient Hispanic and African Americans.
Article in American journal of hypertension, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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19 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Pooled it
- Fibroblast growth factor 23-Klotho and hypertension: experimental and clinical mechanisms.Pediatric nephrology (Berlin, Germany) · 2021Review
- Article
- Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions.Endocrine reviews · 2019Review
- Vitamin D deficiency and risk of cardiovascular diseases: a narrative review.Clinical hypertension · 2018Review
- 25-hydroxyvitamin D Levels was not Associated with Blood Pressure and Arterial Stiffness in Patients with Chronic Kidney Disease.Electrolyte & blood pressure : E & BP · 2017Article
- Association of Serum 25-hydroxy-vitamin D Concentration and Arterial Stiffness among Korean Adults in Single Center.Journal of bone metabolism · 2017Article
- Effect of 1,25(OH)Biomedical reports · 2016Article
- Vitamin D deficiency in the pathogenesis of hypertension: still an unsettled question.Current hypertension reports · 2014Review
- Vitamin D and insulin resistance in postmenopausal Indian women.Indian journal of endocrinology and metabolism · 2014Article
- Testosterone-induced effects on lipids and inflammation.Mediators of inflammation · 2013Review
- Serum 25(OH)D is inversely associated with metabolic syndrome risk profile among urban middle-aged Chinese population.Nutrition journal · 2012Article
- Circulating 25-hydroxyvitamin D levels in relation to blood pressure parameters and hypertension in the Shanghai Women's and Men's Health Studies.The British journal of nutrition · 2012Article
- Vitamin D intake is inversely related to risk of developing metabolic syndrome in African American and white men and women over 20 y: the Coronary Artery Risk Development in Young Adults study.The American journal of clinical nutrition · 2012Article
- Serum 25-hydroxyvitamin D3, parathyroid hormone and blood pressure in an elderly cohort from Germany: a cross-sectional study.Nutrition & metabolism · 2012Article
- Serum vitamin D level and prehypertension among subjects free of hypertension.Kidney & blood pressure research · 2012Article
- Vitamin D: roles in renal and cardiovascular protection.Current opinion in nephrology and hypertension · 2012Review
- Vitamin d, adiposity, and calcified atherosclerotic plaque in african-americans.The Journal of clinical endocrinology and metabolism · 2010Article
- The uncertain significance of low vitamin D levels in African descent populations: a review of the bone and cardiometabolic literature.Progress in cardiovascular diseasesReview
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12 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundSeveral observational studies have recently suggested an inverse association of circulating levels of vitamin D with blood pressure. These findings have been based mainly on Caucasian populations; whether this association also exists among Hispanic and African Americans has yet to be definitively determined. This study investigates the association of 25-hydroxyvitamin D (25[OH]D) with blood pressure in Hispanic and African Americans.
methodsThe data source for this study is the Insulin Resistance Atherosclerosis Family Study (IRASFS), which consists of Hispanic- and African-American families from three US recruitment centers (n =1,334). A variance components model was used to analyze the association of plasma 25[OH]D levels with blood pressure.
resultsAn inverse association was found between 25[OH]D and both systolic (beta for 10 ng/ml difference = -2.05; P < 0.01) and diastolic (beta for 10 ng/ml difference = -1.35; P < 0.001) blood pressure in all populations combined, after adjusting for age, sex, ethnicity, and season of blood draw. Further adjustment for body mass index (BMI) weakened this association (beta for 10 ng/ml difference = -0.94; P = 0.14 and beta for 10 ng/ml difference = -0.64; P = 0.09, respectively).
conclusions25[OH]D levels are significantly inversely associated with blood pressure in Hispanic and African Americans from the IRASFS. However, this association was not significant after adjustment for BMI. Further research is needed to determine the role of BMI in this association. Large, well-designed prospective studies of the effect of vitamin D supplementation on blood pressure may be warranted.
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