ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2009
Epithelial cells in fetal intestine produce chemerin to recruit macrophages.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 64 citations in OpenAlex.
- Development and functional adaptation of intestinal macrophages across the lifespan.Clinical & translational immunology · 2026Review
- GSDMD deficiency mitigates intestinal damage via macrophage pyroptosis control in experimental NEC.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Article
- Review
- New insights into intestinal macrophages in necrotizing enterocolitis: the multi-functional role and promising therapeutic application.Frontiers in immunology · 2023Review
- Establishment of tissue-resident immune populations in the fetus.Seminars in immunopathology · 2022Review
- DMBT1 expression and neutrophil-to-lymphocyte ratio during necrotizing enterocolitis are influenced by impaired perfusion due to cardiac anomalies.Molecular and cellular pediatrics · 2022Article
- Effect of the Microbiome on Intestinal Innate Immune Development in Early Life and the Potential Strategy of Early Intervention.Frontiers in immunology · 2022Review
- Chemerin Regulates Epithelial Barrier Function of Mammary Glands in Dairy Cows.Animals : an open access journal from MDPI · 2021Article
- Role of macrophages in fetal development and perinatal disorders.Pediatric research · 2021Review
- Gestational Age-Specific Complete Blood Count Signatures in Necrotizing Enterocolitis.Frontiers in pediatrics · 2021Article
- MiR-146a-5p Mimic Inhibits NLRP3 Inflammasome Downstream Inflammatory Factors and CLIC4 in Neonatal Necrotizing Enterocolitis.Frontiers in cell and developmental biology · 2020Article
- More Than an Adipokine: The Complex Roles of Chemerin Signaling in Cancer.International journal of molecular sciences · 2019Review
- Antimicrobial and Attractant Roles for Chemerin in the Oral Cavity during Inflammatory Gum Disease.Frontiers in immunology · 2017Article
- Serum chemerin levels are independently associated with quality of life in colorectal cancer survivors: A pilot study.PloS one · 2017Article
- Proteomic analysis of egg white heparin-binding proteins: towards the identification of natural antibacterial molecules.Scientific reports · 2016Article
- The role of chemerin and ChemR23 in stimulating the invasion of squamous oesophageal cancer cells.British journal of cancer · 2016Article
- Immunologic and Hematological Abnormalities in Necrotizing Enterocolitis.Clinics in perinatology · 2015Review
- Local chemerin levels are positively associated with DSS-induced colitis but constitutive loss of CMKLR1 does not protect against development of colitis.Physiological reports · 2015Article
- M1 to M2 macrophage polarization in heparin-binding epidermal growth factor-like growth factor therapy for necrotizing enterocolitis.The Journal of surgical research · 2015Article
- Chemerin, a novel player in inflammatory bowel disease.Cellular & molecular immunology · 2014Review
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
Macrophages are first seen in the fetal intestine at 11-12 wk and rapidly increase in number during the 12- to 22-wk period of gestation. The development of macrophage populations in the fetal intestine precedes the appearance of lymphocytes and neutrophils and does not require the presence of dietary or microbial antigens. In this study, we investigated the role of chemerin, a recently discovered, relatively selective chemoattractant for macrophages, in the recruitment of macrophage precursors to the fetal intestine. Chemerin mRNA/protein expression was measured in jejunoileal tissue from 10- to 24-wk human fetuses, neonates operated for intestinal obstruction, and adults undergoing bariatric surgery. The expression of chemerin in intestinal epithelial cells (IECs) was confirmed by using cultured primary IECs and IEC-like cell lines in vitro. The regulatory mechanisms involved in chemerin expression were investigated by in silico and immunolocalization techniques. IECs in the fetal, but not mature, intestine express chemerin. Chemerin expression peaked in the fetal intestine at 20-24 wk and then decreased to original low levels by full term. During the 10- to 24-wk period, chemerin accounted for most of the macrophage chemotactic activity of cultured fetal IECs. The maturational changes in chemerin expression correlated with the expression of retinoic acid receptor-beta in the intestine. Chemerin is an important mediator of epithelial-macrophage cross talk in the fetal/premature, but not in the mature, intestine. Understanding the regulation of the gut macrophage pool is an important step in development of novel strategies to boost mucosal immunity in premature infants and other patient populations at risk of microbial translocation.
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