ArticleBlood2009
Enhanced development of CD4+ gammadelta T cells in the absence of Itk results in elevated IgE production.
Article in Blood, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
63 citing papers in PubMed, 96 citations in OpenAlex.
- Decoding innate lymphoid cells and innate-like lymphocytes in asthma: pathways to mechanisms and therapies.Journal of biomedical science · 2025Review
- T Cell Development: From T-Lineage Specification to Intrathymic Maturation.Advances in experimental medicine and biology · 2025Review
- E proteins control the development of NKγδT cells through their invariant T cell receptor.Nature communications · 2024Article
- Article
- Article
- Identification of distinct functional thymic programming of fetal and pediatric human γδ thymocytes via single-cell analysis.Nature communications · 2022Article
- ITK independent development of Th17 responses during hypersensitivity pneumonitis driven lung inflammation.Communications biology · 2022Article
- Systemic innate and adaptive immune responses to SARS-CoV-2 as it relates to other coronaviruses.Human vaccines & immunotherapeutics · 2020Review
- Innate-like Lymphocytes and Innate Lymphoid Cells in Asthma.Clinical reviews in allergy & immunology · 2020Review
- The phenotypic changes of γδ T cells in COVID-19 patients.Journal of cellular and molecular medicine · 2020Article
- T Cell Reprogramming Against Cancer.Methods in molecular biology (Clifton, N.J.) · 2020Review
- Gamma/Delta T Cells in the Course of Healthy Human Pregnancy: Cytotoxic Potential and the Tendency of CD8 Expression Make CD56+ γδT Cells a Unique Lymphocyte Subset.Frontiers in immunology · 2020Article
- Genetic Deficiency and Biochemical Inhibition of ITK Affect Human Th17, Treg, and Innate Lymphoid Cells.Journal of clinical immunology · 2019Article
- The Potent ITK/BTK Inhibitor Ibrutinib Is Effective for the Treatment of Experimental Visceral Leishmaniasis Caused by Leishmania donovani.The Journal of infectious diseases · 2019Article
- TIM-3 and TIM-1 Could Regulate DecidualJournal of immunology research · 2019Article
- Interleukin-2-Inducible T-Cell Kinase Deficiency Impairs Early Pulmonary Protection AgainstFrontiers in immunology · 2019Article
- Id3 Restricts γδ NKT Cell Expansion by Controlling Egr2 and c-Myc Activity.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells.Nature communications · 2017Article
- IL-33 Drives Augmented Responses to Ozone in Obese Mice.Environmental health perspectives · 2017Article
- A Special Connection between γδ T Cells and Natural Antibodies?Archivum immunologiae et therapiae experimentalis · 2016Review
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
The Tec kinase Itk is critical for the development of alphabeta T cells as well as differentiation of CD4(+) T cells into Th2 cells. Itk null mice have defects in the production of Th2 cytokines; however, they paradoxically have significant elevations in serum IgE. Here we show that Itk null mice have increased numbers of gammadelta T cells in the thymus and spleen. This includes elevated numbers of CD4(+) gammadelta T cell, the majority of which carry the Vgamma1.1 and Vdelta6.2/3 gammadelta T-cell receptor with a distinct phenotype. The development of these CD4(+) gammadelta T cells is T cell intrinsic, independent of either major histocompatibility complex class I or class II, and is favored during development in the absence of Itk. Itk null CD4(+) gammadelta T cells secrete significant amounts of Th2 cytokines and can induce the secretion of IgE by wild-type B cells. Our data indicate that Itk plays important role in regulating gammadelta T-cell development and function. In addition, our data indicate that the elevated IgE observed in Itk-deficient mice is due in part to the enhanced development of CD4(+) gammadelta T cells in the absence of Itk.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.