SynthesisClinical journal of the American Society of Nephrology : CJASN2009
Searching for genes that matter in acute kidney injury: a systematic review.
Synthesis in Clinical journal of the American Society of Nephrology : CJASN, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 5 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Genome-wide association study of hospitalized patients and acute kidney injury.Kidney international · 2024Pooled it
- Genetic Variation and Hot Flashes: A Systematic Review.The Journal of clinical endocrinology and metabolism · 2020Pooled it
- Genetic predisposition to acute kidney injury--a systematic review.BMC nephrology · 2015Pooled it
- Genetic susceptibility to renal scar formation after urinary tract infection: a systematic review and meta-analysis of candidate gene polymorphisms.Pediatric nephrology (Berlin, Germany) · 2011Pooled it
- Genetic risk for recurrent urinary tract infections in humans: a systematic review.Journal of biomedicine & biotechnology · 2010Pooled it
- Post-operative infection treatment in cardiac surgery: current practices and future directions.Perioperative medicine (London, England) · 2025Review
- Genetic association studies in critically ill patients: protocol for a systematic review.Systematic reviews · 2023Article
- Sepsis-associated acute kidney injury: consensus report of the 28th Acute Disease Quality Initiative workgroup.Nature reviews. Nephrology · 2023Review
- Subphenotypes in acute kidney injury: a narrative review.Critical care (London, England) · 2022Review
- The horizon of pediatric cardiac critical care.Frontiers in pediatrics · 2022Review
- Genetic Susceptibility to Acute Kidney Injury.Journal of clinical medicine · 2021Review
- Clinical and experimental approaches for imaging of acute kidney injury.Clinical and experimental nephrology · 2021Review
- Acute Kidney Injury in the Intensive Care Unit: The Most Reliable Way to Predict the Future is to Create It.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021Article
- ACUTE KIDNEY INJURY AFTER OPEN-HEART SURGERY PROCEDURES.Acta clinica Croatica · 2021Review
- Acute Kidney Injury Associated with Cardiac Surgery: a Comprehensive Literature Review.Brazilian journal of cardiovascular surgery · 2020Review
- [Acute kidney injury: from creatinine to KIM‑1?]Der Internist · 2019Review
- Association of genetic polymorphisms with acute kidney injury after cardiac surgery in a Southeast Asian population.PloS one · 2019Article
- Predicting acute kidney injury: current status and future challenges.Journal of nephrology · 2018Review
- Article
- Between chromatin and SNPs: genetic variability and the susceptibility to acute kidney injury.Critical care (London, England) · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
objectivesIdentifying patients who may develop acute kidney injury (AKI) remains challenging, as clinical determinants explain only a portion of individual risk. Another factor that likely affects risk is intrinsic genetic variability. Therefore, a systematic review of studies was performed that related the development or prognosis of AKI to genetic variation. DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: MEDLINE, EMBASE, HuGEnet, SCOPUS, and Web of Science were searched for articles from 1950 to Dec 2007. Two independent researchers screened articles using predetermined criteria. Studies were assessed for methodological quality via an aggregate scoring system.
resultsThe 16 included studies were of cohort or case-cohort design and investigated 35 polymorphisms in 21 genes in association with AKI. Fifteen gene-gene interactions were also investigated in four separate studies. Study populations were primarily premature infants or adults who were critically ill or postcardiac bypass patients. Among the studies, five different definitions of AKI were used. Only one polymorphism, APO E e2/e3/e4, had greater than one study showing a significant impact (P < 0.05) on AKI incidence. The mean quality score of 5.8/10 (range four to nine), heterogeneity in the studies, and the dearth of studies precluded additional meta-analysis of the results.
conclusionsCurrent association studies are unable to provide definitive evidence linking genetic variation to AKI. Future success will require a narrow consensus definition of AKI, rigorous epidemiologic techniques, and a shift from a priori hypothesis-driven to genome-wide association studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.