ArticleMicrobiology (Reading, England)2009
Identification of conserved antigens for early serodiagnosis of relapsing fever Borrelia.
Article in Microbiology (Reading, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- Characterization of Immunological Responses toMicrobiology spectrum · 2022Article
- Novel approaches for the serodiagnosis of louse-borne relapsing fever.Frontiers in cellular and infection microbiology · 2022Article
- Simultaneous Detection and Differentiation of Clinically Relevant Relapsing FeverJournal of clinical microbiology · 2021Article
- Visualizing Borrelia burgdorferi Infection Using a Small-Molecule Imaging Probe.Journal of clinical microbiology · 2021Article
- Characterization of a Borrelia miyamotoi membrane antigen (BmaA) for serodiagnosis of Borrelia miyamotoi disease.Ticks and tick-borne diseases · 2020Article
- Humoral immune response of pigs, Sus scrofa domesticus, upon repeated exposure to blood-feeding by Ornithodoros turicata Duges (Ixodida: Argasidae).Parasites & vectors · 2020Article
- Case report: A retrospective serological analysis indicating human exposure to tick-borne relapsing fever spirochetes in Sonora, Mexico.PLoS neglected tropical diseases · 2019Article
- Variable Major Proteins as Targets for Specific Antibodies against Borrelia miyamotoi.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Tick-Borne Relapsing Fever Spirochetes in the Americas.Veterinary sciences · 2016Article
- Borrelia burgdorferi elongation factor EF-Tu is an immunogenic protein during Lyme borreliosis.Emerging microbes & infections · 2015Article
- Fibronectin-binding protein of Borrelia hermsii expressed in the blood of mice with relapsing fever.Infection and immunity · 2014Article
- Sequence analysis and serological responses against Borrelia turicatae BipA, a putative species-specific antigen.PLoS neglected tropical diseases · 2013Article
- Alp, an arthropod-associated outer membrane protein of Borrelia species that cause relapsing fever.Infection and immunity · 2012Article
- Characteristics of Borrelia hermsii infection in human hematopoietic stem cell-engrafted mice mirror those of human relapsing fever.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Immunoproteomic analysis of human serological antibody responses to vaccination with whole-cell pertussis vaccine (WCV).PloS one · 2010Article
- A novel surface antigen of relapsing fever spirochetes can discriminate between relapsing fever and Lyme borreliosis.Clinical and vaccine immunology : CVI · 2010Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Borrelia hermsii is a blood-borne pathogen transmitted by the argasid tick Ornithodoros hermsi. Since spirochaete clearance in mice is associated with an IgM-mediated response, an immunoproteomic analysis was used to identify proteins reactive with IgM. We report that IgM from both mice and human patients infected with B. hermsii not only reacted with the previously identified variable membrane proteins but also identified candidate antigens including heat-shock proteins, an adhesin protein, ABC transporter proteins, flagellar proteins, housekeeping proteins, an immune evasion protein, and proteins with unknown function. Furthermore, IgM reactivity to recombinant glycerophosphodiester phosphodiesterase was detected during early spirochaete infection and prior to a detectable IgG response. Lastly, a conserved hypothetical protein was produced in Escherichia coli and tested with immune serum against B. hermsii and Borrelia recurrentis. These results identify a much larger set of immunoreactive proteins, and could help in the early serodiagnosis of this tick-borne infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.