ArticleBiosensors & bioelectronics2009
Ultrasensitive Qbeta phage analysis using fluorescence correlation spectroscopy on an optofluidic chip.
Article in Biosensors & bioelectronics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 47 citations in OpenAlex.
- Functional Properties of Amino Acid Side Chains as Biomarkers of Extraterrestrial Life.Astrobiology · 2018Article
- Optofluidic devices with integrated solid-state nanopores.Mikrochimica acta · 2016Article
- Liquid Core ARROW Waveguides: A Promising Photonic Structure for Integrated Optofluidic Microsensors.Micromachines · 2016Review
- Electro-optical detection of single λ-DNA.Chemical communications (Cambridge, England) · 2015Article
- Integration of programmable microfluidics and on-chip fluorescence detection for biosensing applications.Biomicrofluidics · 2014Article
- Hybrid optofluidic integration.Lab on a chip · 2013Article
- Optofluidic Microsystems for Chemical and Biological Analysis.Nature photonics · 2011Article
- Tailorable integrated optofluidic filters for biomolecular detection.Lab on a chip · 2011Article
- Enhancing single molecule imaging in optofluidics and microfluidics.International journal of molecular sciences · 2011Review
- Optimized piranha etching process for SU8-based MEMS and MOEMS construction.Journal of micromechanics and microengineering : structures, devices, and systems · 2010Article
- Microfluidics in macro-biomolecules analysis: macro inside in a nano world.Analytical and bioanalytical chemistry · 2010Review
- Hollow ARROW Waveguides on Self-Aligned Pedestals for Improved Geometry and Transmission.IEEE photonics technology letters : a publication of the IEEE Laser and Electro-optics Society · 2010Article
- Optofluidic notch filter integration by lift-off of thin films.Optics express · 2010Article
- Micropore and nanopore fabrication in hollow antiresonant reflecting optical waveguides.Journal of micro/nanolithography, MEMS, and MOEMS : JM3 · 2010Article
- Multi-mode mitigation in an optofluidic chip for particle manipulation and sensing.Optics express · 2009Article
- Signal-to-noise Enhancement in Optical Detection of Single Viruses with Multi-spot Excitation.IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics SocietyArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
We demonstrate detection and analysis of the Qbeta bacteriophage on the single virus level using an integrated optofluidic biosensor. Individual Qbeta phages with masses on the order of attograms were sensed and analyzed on a silicon chip in their natural liquid environment without the need for virus immobilization. The diffusion coefficient of the viruses was extracted from the fluorescence signal by means of fluorescence correlation spectroscopy (FCS) and found to be 15.90+/-1.50 microm(2)/s in excellent agreement with previously published values. The aggregation and disintegration of the phage were also observed. Virus flow velocities determined by FCS were in the 60-300 microm/s range. This study suggests considerable potential for an inexpensive and portable sensor capable of discrimination between viruses of different sizes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.