ReviewDrug and alcohol dependence2009
Principles of laboratory assessment of drug abuse liability and implications for clinical development.
Review in Drug and alcohol dependence, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
116 citing papers in PubMed, 2 syntheses or guidelines pooled it, 207 citations in OpenAlex.
- A Systematic Review of Laboratory Evidence for the Abuse Potential of Tramadol in Humans.Frontiers in psychiatry · 2019Pooled it
- Inhalation of Alcohol Vapor: Measurement and Implications.Alcoholism, clinical and experimental research · 2017Pooled it
- Impact of reduced nicotine content on behavioral economic measures of cigarette reinforcement in adolescents who smoke cigarettes.Drug and alcohol dependence · 2023Trial
- Acute drug effects differentially predict desire to take dextroamphetamine again for work and recreation.Psychopharmacology · 2021Trial
- Detection of acute 3,4-methylenedioxymethamphetamine (MDMA) effects across protocols using automated natural language processing.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Effects of non-tobacco flavors and nicotine on e-cigarette product appeal among young adult never, former, and current smokers.Drug and alcohol dependence · 2019Trial
- A randomized, double-blind, placebo-controlled, crossover study to evaluate the human abuse liability of solriamfetol, a selective dopamine and norepinephrine reuptake inhibitor.Journal of psychopharmacology (Oxford, England) · 2018Trial
- Drug liking and wanting, not impulsive action or reflection is increased by 4-fluoroamphetamine.Psychopharmacology · 2018Trial
- Subjective cannabis effects as part of a developing disorder in adolescents and emerging adults.Journal of abnormal psychology · 2018Trial
- Characterizing the subjective, observer-rated, and physiological effects of hydromorphone relative to heroin in a human laboratory study.Psychopharmacology · 2018Trial
- Electronic cigarette user plasma nicotine concentration, puff topography, heart rate, and subjective effects: Influence of liquid nicotine concentration and user experience.Experimental and clinical psychopharmacology · 2017Trial
- Cocaine self-administration disrupted by the N-methyl-D-aspartate receptor antagonist ketamine: a randomized, crossover trial.Molecular psychiatry · 2017Trial
- A window into the intoxicated mind? Speech as an index of psychoactive drug effects.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Trial
- Assessment of the abuse liability of a dual orexin receptor antagonist: a crossover study of almorexant and zolpidem in recreational drug users.CNS drugs · 2014Trial
- Cognitive effects of intramuscular ketamine and oral triazolam in healthy volunteers.Psychopharmacology · 2013Trial
- Electronic cigarettes: effective nicotine delivery after acute administration.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2013Trial
- Effects of varenicline on abstinence and smoking reward following a programmed lapse.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2013Trial
- Intranasal oxycodone self-administration in non-dependent opioid abusers.Experimental and clinical psychopharmacology · 2012Trial
- Acute effects of electronic nicotine delivery system liquid nicotine form and sweet enhancer among people who use inhaled tobacco products.Experimental and clinical psychopharmacology · 2026Article
- Bifunctional Modulation of NMDA and Opioid Receptors in Ketamine Reinforcement and Misuse: Implications for Substance Use Disorder Treatment.Biological psychiatry · 2026Review
56 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Abuse liability testing plays an important role in informing drug development, regulatory processes, and clinical practice. This paper describes the current "gold standard" methodologies that are used for laboratory assessments of abuse liability in non-human and human subjects. Particular emphasis is given to procedures such as non-human drug discrimination, self-administration, and physical dependence testing, and human dose-effect abuse liability studies that are commonly used in regulatory submissions to governmental agencies. The potential benefits and risks associated with the inclusion of measures of abuse liability in industry-sponsored clinical trials is discussed. Lastly, it is noted that many factors contribute to patterns of drug abuse and dependence outside of the laboratory setting and positive or negative signals in abuse liability studies do not always translate to high or low levels of actual abuse or dependence. Well-designed patient and physician education, pharmacovigilance, and postmarketing surveillance can reduce the diversion and misuse of drugs with abuse liability and can effectively foster the protection and promotion of public health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.