ReviewDifferentiation; research in biological diversity2009
Epigenetic gene regulation in stem cells and correlation to cancer.
Review in Differentiation; research in biological diversity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Research recommendations for selected IARC-classified agents.Environmental health perspectives · 2010Pooled it
- A novel approach to enhance glioblastoma multiforme treatment efficacy: non-coding RNA targeted therapy and adjuvant approaches.Clinical epigenetics · 2025Review
- Hinokitiol Inhibits Breast Cancer Cells In Vitro Stemness-Progression and Self-Renewal with Apoptosis and Autophagy Modulation via the CD44/Nanog/SOX2/Oct4 Pathway.International journal of molecular sciences · 2024Article
- Phenotypic Plasticity - Alternate Transcriptional Programs Driving Treatment Resistant Prostate Cancer.Critical reviews in oncogenesis · 2022Review
- Repression of PCGF1 Decreases the Proliferation of Glioblastoma Cells in Association with Inactivation of c-Myc Signaling Pathway.OncoTargets and therapy · 2020Article
- Generation of High-Throughput Three-Dimensional Tumor Spheroids for Drug Screening.Journal of visualized experiments : JoVE · 2018Article
- Cell biology of glioblastoma multiforme: from basic science to diagnosis and treatment.Medical oncology (Northwood, London, England) · 2018Review
- Polycomb group expression signatures in the malignant progression of gliomas.Oncology letters · 2017Article
- Nephrotoxicity of epigenetic inhibitors used for the treatment of cancer.Chemico-biological interactions · 2016Article
- [Advances on Driver Mutations of Small Cell Lung Cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2016Review
- Glioblastoma stem cells (GSCs) epigenetic plasticity and interconversion between differentiated non-GSCs and GSCs.Genes & diseases · 2015Article
- Review
- Epigenetic changes in p21 expression in renal cells after exposure to bromate.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- Chloroquine eliminates cancer stem cells through deregulation of Jak2 and DNMT1.Stem cells (Dayton, Ohio) · 2014Article
- Role of EZH2 polymorphisms in esophageal squamous cell carcinoma risk in Han Chinese population.International journal of molecular sciences · 2014Article
- Epigenetic choreography of stem cells: the DNA demethylation episode of development.Cellular and molecular life sciences : CMLS · 2014Review
- A model for the epigenetic switch linking inflammation to cell transformation: deterministic and stochastic approaches.PLoS computational biology · 2014Article
- A single nucleotide polymorphism in EZH2 predicts overall survival rate in patients with cholangiocarcinoma.Oncology letters · 2013Article
- Heterogeneity of circulating epithelial tumour cells from individual patients with respect to expression profiles and clonal growth (sphere formation) in breast cancer.Ecancermedicalscience · 2013Article
- Epigenetics of colorectal cancer.Gastroenterology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Through the classic study of genetics, much has been learned about the regulation and progression of human disease. Specifically, cancer has been defined as a disease driven by genetic alterations, including mutations in tumor-suppressor genes and oncogenes, as well as chromosomal abnormalities. However, the study of normal human development has identified that in addition to classical genetics, regulation of gene expression is also modified by 'epigenetic' alterations including chromatin remodeling and histone variants, DNA methylation, the regulation of polycomb group proteins, and the epigenetic function of non-coding RNA. These changes are modifications inherited during both meiosis and mitosis, yet they do not result in alterations of the actual DNA sequence. A number of biological questions are directly influenced by epigenetics, such as how does a cell know when to divide, differentiate or remain quiescent, and more importantly, what happens when these pathways become altered? Do these alterations lead to the development and/or progression of cancer? This review will focus on summarizing the limited current literature involving epigenetic alterations in the context of human cancer stems cells (CSCs). The extent to which epigenetic changes define cell fate, identity, and phenotype are still under intense investigation, and many questions remain largely unanswered. Before discussing epigenetic gene silencing in CSCs, the different classifications of stem cells and their properties will be introduced. This will be followed by an introduction to the different epigenetic mechanisms. Finally, there will be a discussion of the current knowledge of epigenetic modifications in stem cells, specifically what is known from rodent systems and established cancer cell lines, and how they are leading us to understand human stem cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.