ArticleJACC. Cardiovascular imaging2009
Atherosclerotic and thrombogenic neointima formed over sirolimus drug-eluting stent: an angioscopic study.
Article in JACC. Cardiovascular imaging, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Outcomes of Percutaneous Coronary Intervention for In-Stent Restenosis Versus De Novo Lesions: A Meta-Analysis.Journal of the American Heart Association · 2023Pooled it
- Remodeling pattern is related to the degree of coronary plaque regression induced by pitavastatin: a sub-analysis of the TOGETHAR trial with intravascular ultrasound and coronary angioscopy.Heart and vessels · 2015Trial
- Article
- Case report of a peripheral artery disease patient with its aetiology clarified by retrograde angioscopy.European heart journal. Case reports · 2022Article
- Article
- Arterial Healing 10 Months After Implantation of an Ultrathin-Strut, Biodegradable-Polymer, Sirolimus-Eluting Stent - An Angioscopic Study.Circulation reports · 2021Article
- Impact of diabetes mellitus on the early-phase arterial healing after drug-eluting stent implantation.Cardiovascular diabetology · 2020Observational
- The Effects of Pro-Inflammatory and Anti-Inflammatory Agents for the Suppression of Intimal Hyperplasia: An Evidence-Based Review.International journal of environmental research and public health · 2020Review
- Are we curing one evil with another? A translational approach targeting the role of neoatherosclerosis in late stent failure.European heart journal supplements : journal of the European Society of Cardiology · 2020Article
- The Current Literature on Bioabsorbable Stents: a Review.Current atherosclerosis reports · 2019Review
- Intravascular imaging analysis of a drug-eluting balloon followed by a bare metal stent compared to a drug-eluting stent for treatment of de novo lesions.The Korean journal of internal medicine · 2019Article
- Early vessel healing after implantation of biodegradable-polymer and durable-polymer drug-eluting stent: 3-month angioscopic evaluation of the RESTORE registry.The international journal of cardiovascular imaging · 2019Article
- In Vivo Illustration of Dendrite Formation on a Mobile Thrombus within a Wallstent in an Iliac Artery: A Fractal Phenomenon.Annals of vascular diseases · 2019Article
- TGFβ, smooth muscle cells and coronary artery disease: a review.Cellular signalling · 2019Review
- The comparison of early healing 1-month after PCI among CoCr-everolimus-eluting stent (EES), biodegradable polymer (BP)-EES and BP-sirolimus-eluting stent: Insights from OFDI and coronary angioscopy.International journal of cardiology. Heart & vasculature · 2018Article
- Impact of out-stent plaque characteristics on vascular response after second generation drug-eluting stent implantation: iMAP-intravascular ultrasound and angioscopic study.International journal of cardiology. Heart & vasculature · 2018Article
- The Return of the Vulnerable Plaque: Optical Coherence Tomography Imaging of a Case of a Late In-Stent Restenotic Chronic Total Occlusion.The International journal of angiology : official publication of the International College of Angiology, Inc · 2017Article
- A case of in-stent restenosis with pathologically proven chronic inflammation seven years after sirolimus-eluting stent implantation.Journal of cardiology cases · 2017Article
- Localization of in-stent neoatherosclerosis in relation to curvatures and bifurcations after stenting.Journal of thoracic disease · 2016Article
- Impact of optical coherence tomography- and coronary angioscopy-assessed neointimal tissue characteristics on occurrence of periprocedural myonecrosis in patients with in-stent restenosis.The international journal of cardiovascular imaging · 2016Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWe sought to examine by angioscopy the neointima formation and thrombogenic potential of the neointima after deployment of a drug-eluting stent (DES).
backgroundLate stent thrombosis after DES implantation, a major safety concern, has been associated with poor strut coverage by neointima. Intracoronary angioscopy provides a method for visual evaluation of stent coverage by neointima and detection of thrombus in the stented coronary segment.
methodsPatients undergoing implantation of a sirolimus DES (n = 57) were serially examined by angioscopy immediately after (baseline) and again at 10 months (follow-up) after implantation. The angioscopic color grade of the neointima from white to yellow was assessed in a semiquantitative manner. Stent coverage was classified into not covered (Grade 0), covered by a thin layer (Grade 1), or buried under neointima (Grade 2). The thrombogenic potential of the neointima was evaluated by the prevalence of thrombus on the neointima.
resultsThe maximum yellow color grade of the neointima within DES-implanted lesions increased significantly from baseline to follow-up (1.4 +/- 1.1 vs. 1.9 +/- 0.6, p = 0.0008). Even among lesions without yellow color at baseline, yellow color was detected in 94% (17 of 18) of lesions at follow-up. The prevalence of thrombus was significantly higher on the yellow than on the white neointimal areas. Thrombus was detected on yellow and/or Grade-0/1 neointima, but never on the white Grade-2 neointima.
conclusionsSirolimus DES promoted formation of atherosclerotic yellow neointima in the stent-implanted lesion at 10-month follow-up. Thrombus was detected more often on the yellow area than on the white area and was never detected where a stent was buried under white neointima. These data suggest that the increased potential risk of late stent thrombosis in DES lesions may be due to the newly formed yellow neotima and cholesterol-laden plaque.
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