ArticleMolecular and cellular biology1991
Sequence requirements for transcriptional arrest in exon 1 of the human adenosine deaminase gene.
Article in Molecular and cellular biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 31 citations in OpenAlex.
- Glucocorticoid resistance in a multiple myeloma cell line is regulated by a transcription elongation block in the glucocorticoid receptor gene (NR3C1).British journal of haematology · 2009Article
- Molecular events involved in up-regulating human Na+-independent neutral amino acid transporter LAT1 during T-cell activation.The Biochemical journal · 2001Article
- Control of transcription arrest in intron 1 of the murine adenosine deaminase gene.Molecular and cellular biology · 1994Article
- Sp1 is essential for both enhancer-mediated and basal activation of the TATA-less human adenosine deaminase promoter.Nucleic acids research · 1994Article
- Hereditary overexpression of adenosine deaminase in erythrocytes: evidence for a cis-acting mutation.American journal of human genetics · 1993Article
- Regulation of eukaryotic gene expression by transcriptional attenuation.Molecular biology of the cell · 1993Review
- Expression of mRNA encoding the macrophage colony-stimulating factor receptor (c-fms) is controlled by a constitutive promoter and tissue-specific transcription elongation.Molecular and cellular biology · 1993Article
- Functional analysis of a stable transcription arrest site in the first intron of the murine adenosine deaminase gene.Molecular and cellular biology · 1993Article
- Transcription elongation in the human c-myc gene is governed by overall transcription initiation levels in Xenopus oocytes.Molecular and cellular biology · 1993Article
- An S-phase specific release from a transcriptional block regulates the expression of mouse ribonucleotide reductase R2 subunit.The EMBO journal · 1992Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
We have previously demonstrated that a transcriptional arrest site exists in exon 1 of the human adenosine deaminase (ADA) gene and that this site may play a role in ADA gene expression (Z. Chen, M. L. Harless, D. A. Wright, and R. E. Kellems, Mol. Cell. Biol. 10:4555-4564, 1990). Sequences involved in this process are not known precisely. To further define the template requirements for transcriptional arrest within exon 1 of the human ADA gene, various ADA templates were constructed and their abilities to confer transcriptional arrest were determined following injection into Xenopus oocytes. The exon 1 transcriptional arrest signal functioned downstream of several RNA polymerase II promoters and an RNA polymerase III promoter, implying that the transcriptional arrest site in exon 1 of the ADA gene is promoter independent. We identified a 43-bp DNA fragment which functions as a transcriptional arrest signal. Additional studies showed that the transcriptional arrest site functioned only in the naturally occurring orientation. Therefore, we have identified a 43-bp DNA fragment which functions as a transcriptional arrest signal in an orientation-dependent and promoter-independent manner. On the basis of our findings, we hypothesize that tissue-specific expression of the ADA gene is governed by factors that function as antiterminators to promote transcriptional readthrough of the exon 1 transcriptional arrest site.
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