ArticleAmerican journal of human genetics2009
Genome-wide insights into the patterns and determinants of fine-scale population structure in humans.
Article in American journal of human genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Charcot-Marie-Tooth gene, SBF2, associated with taxane-induced peripheral neuropathy in African Americans.Oncotarget · 2016Trial
- Applying traditional and machine learning-based GWAS approaches for marker-trait identification in wheat.Frontiers in plant science · 2025Article
- Principal Component Analyses (PCA)-based findings in population genetic studies are highly biased and must be reevaluated.Scientific reports · 2022Article
- A deep learning framework for characterization of genotype data.G3 (Bethesda, Md.) · 2022Article
- Common Treatment, Common Variant: Evolutionary Prediction of Functional Pharmacogenomic Variants.Journal of personalized medicine · 2021Article
- The three-hybrid genetic composition of an Ecuadorian population using AIMs-InDels compared with autosomes, mitochondrial DNA and Y chromosome data.Scientific reports · 2019Article
- Complex genetic patterns in human arise from a simple range-expansion model over continental landmasses.PloS one · 2018Article
- A panel of 130 autosomal single-nucleotide polymorphisms for ancestry assignment in five Asian populations and in Caucasians.Forensic science, medicine, and pathology · 2017Article
- Regional surnames and genetic structure in Great Britain.Transactions (Institute of British Geographers : 1965) · 2016Article
- Article
- Methods and models for unravelling human evolutionary history.Nature reviews. Genetics · 2015Review
- Impact of SNPs on methylation readouts by Illumina Infinium HumanMethylation450 BeadChip Array: implications for comparative population studies.BMC genomics · 2015Article
- Fine-scale human genetic structure in Western France.European journal of human genetics : EJHG · 2015Article
- Rare variation facilitates inferences of fine-scale population structure in humans.Molecular biology and evolution · 2015Article
- Recent human adaptation: genomic approaches, interpretation and insights.Nature reviews. Genetics · 2013Review
- Omics technologies and the study of human ageing.Nature reviews. Genetics · 2013Review
- Population structure in a comprehensive genomic data set on human microsatellite variation.G3 (Bethesda, Md.) · 2013Article
- Human loci involved in drug biotransformation: worldwide genetic variation, population structure, and pharmacogenetic implications.Human genetics · 2013Article
- A genome-wide analysis of populations from European Russia reveals a new pole of genetic diversity in northern Europe.PloS one · 2013Article
- Fine-scale patterns of population stratification confound rare variant association tests.PloS one · 2013Article
Corrections and comments
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Authors and funding
3 authors.
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Abstract
Studying genomic patterns of human population structure provides important insights into human evolutionary history and the relationship among populations, and it has significant practical implications for disease-gene mapping. Here we describe a principal component (PC)-based approach to studying intracontinental population structure in humans, identify the underlying markers mediating the observed patterns of fine-scale population structure, and infer the predominating evolutionary forces shaping local population structure. We applied this methodology to a data set of 650K SNPs genotyped in 944 unrelated individuals from 52 populations and demonstrate that, although typical PC analyses focus on the top axes of variation, substantial information about population structure is contained in lower-ranked PCs. We identified 18 significant PCs, some of which distinguish individual populations. In addition to visually representing sample clusters in PC biplots, we estimated the set of all SNPs significantly correlated with each of the most informative axes of variation. These polymorphisms, unlike ancestry-informative markers (AIMs), constitute a much larger set of loci that drive genomic signatures of population structure. The genome-wide distribution of these significantly correlated markers can largely be accounted for by the stochastic effects of genetic drift, although significant clustering does occur in genomic regions that have been previously implicated as targets of recent adaptive evolution.
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