ArticleExperimental cell research2009
Evidence for a direct involvement of hMSH5 in promoting ionizing radiation induced apoptosis.
Article in Experimental cell research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Is Male Infertility an Early Warning of More Serious Diseases?Endocrinology · 2026Review
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- Germline Genetic Variants and Lung Cancer Survival in African Americans.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017Article
- Regulation of alternative splicing in human obesity loci.Obesity (Silver Spring, Md.) · 2016Article
- Sex, Scavengers, and Chaperones: Transcriptome Secrets of Divergent Symbiodinium Thermal Tolerances.Molecular biology and evolution · 2016Article
- Proteomic Analysis Reveals a Novel Mutator S (MutS) Partner Involved in Mismatch Repair Pathway.Molecular & cellular proteomics : MCP · 2016Article
- hMSH5 Facilitates the Repair of Camptothecin-induced Double-strand Breaks through an Interaction with FANCJ.The Journal of biological chemistry · 2015Article
- DNA damage induced MutS homologue hMSH4 acetylation.International journal of molecular sciences · 2013Article
- Pro-crossover factors regulate damage-dependent apoptosis in the Caenorhabditis elegans germ line.Cell death and differentiation · 2013Article
- MutS Homologues hMSH4 and hMSH5: Genetic Variations, Functions, and Implications in Human Diseases.Current genomics · 2013Article
- Identification of potential biomarkers from microarray experiments using multiple criteria optimization.Cancer medicine · 2013Article
- MutS homologue hMSH5: recombinational DSB repair and non-synonymous polymorphic variants.PloS one · 2013Article
- Transancestral mapping of the MHC region in systemic lupus erythematosus identifies new independent and interacting loci at MSH5, HLA-DPB1 and HLA-G.Annals of the rheumatic diseases · 2012Article
- MutS homologue hMSH5: role in cisplatin-induced DNA damage response.Molecular cancer · 2012Article
- Review
- hMSH5 is a nucleocytoplasmic shuttling protein whose stability depends on its subcellular localization.Nucleic acids research · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Although increasing evidence has suggested that the hMSH5 protein plays an important role in meiotic and mitotic DNA recombinational repair, its precise functions in recombination and DNA damage response are presently elusive. Here we show that the interaction between hMSH5 and c-Abl confers ionizing radiation (IR)-induced apoptotic response by promoting c-Abl activation and p73 accumulation, and these effects are greatly enhanced in cells expressing hMSH5(P29S) (i.e. the hMSH5 variant possessing a proline to serine change within the N-terminal (Px)(5) dipeptide repeat). Our current study provides the first evidence that the (Px)(5) dipeptide repeat plays an important role in modulating the interaction between hMSH5 and c-Abl and alteration of this dipeptide repeat in hMSH5(P29S) leads to increased IR sensitivity owing to enhanced caspase-3-mediated apoptosis. In addition, RNAi-mediated hMSH5 silencing leads to the reduction of apoptosis in IR-treated cells. In short, this study implicates a role for hMSH5 in DNA damage response involving c-Abl and p73, and suggests that mutations impairing this process could significantly affect normal cellular responses to anti-cancer treatments.
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Registered trials
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