ReviewCurrent opinion in genetics & development2009
Lipid-modified morphogens: functions of fats.
Review in Current opinion in genetics & development, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Spatial Lipidomic Profiling of Mouse Joint Tissue Demonstrates the Essential Role of PHOSPHO1 in Growth Plate Homeostasis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023Article
- Endoplasmic Reticulum Export of GPI-Anchored Proteins.International journal of molecular sciences · 2019Review
- Endogenous ghrelin-O-acyltransferase (GOAT) acylates local ghrelin in the hippocampus.Journal of neurochemistry · 2018Article
- Wnt signaling in cardiovascular disease: opportunities and challenges.Current opinion in lipidology · 2017Review
- Yeast Gup1(2) Proteins Are Homologues of the Hedgehog Morphogens Acyltransferases HHAT(L): Facts and Implications.Journal of developmental biology · 2016Review
- Acute alcohol exposure during mouse gastrulation alters lipid metabolism in placental and heart development: Folate prevention.Birth defects research. Part A, Clinical and molecular teratology · 2016Article
- Seeing is believing: Wnt3 localization in the gut epithelium.Cell research · 2016Article
- APP Receptor? To Be or Not To Be.Trends in pharmacological sciences · 2016Review
- Förster resonance energy transfer-based cholesterolysis assay identifies a novel hedgehog inhibitor.Analytical biochemistry · 2015Article
- The Hedgehog signalling pathway in bone formation.International journal of oral science · 2015Review
- Single-cell imaging of Wnt palmitoylation by the acyltransferase porcupine.Nature chemical biology · 2014Article
- Conformational transition of membrane-associated terminally acylated HIV-1 Nef.Structure (London, England : 1993) · 2013Article
- Protein trafficking abnormalities in Drosophila tissues with impaired activity of the ZIP7 zinc transporter Catsup.Development (Cambridge, England) · 2013Article
- Biogenesis of the Saccharomyces cerevisiae pheromone a-factor, from yeast mating to human disease.Microbiology and molecular biology reviews : MMBR · 2012Review
- Cancer stem cells: potential target for bioactive food components.The Journal of nutritional biochemistry · 2012Review
- Extracellular movement of signaling molecules.Developmental cell · 2011Review
- Role of fatty acid transporters in epidermis: Implications for health and disease.Dermato-endocrinology · 2011Article
- Lipid modifications of Sonic hedgehog ligand dictate cellular reception and signal response.PloS one · 2011Article
- The chemical toolbox for monitoring protein fatty acylation and prenylation.Nature chemical biology · 2010Review
- Mechanism and evolution of cytosolic Hedgehog signal transduction.Development (Cambridge, England) · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Despite their location in the aqueous extracellular environment, a number of secreted proteins carry hydrophobic lipid modifications. These modifications include glycosylphosphatidylinositol, cholesterol, and both saturated and unsaturated fatty acids, and they are attached in the secretory pathway by different classes of enzymes. Lipid attachments make crucial contributions to protein function in vivo through a diverse array of mechanisms. They can promote protein maturation and secretion, membrane tethering, targeting to specific membrane subdomains, or receptor binding and activation. Additionally, secretion of lipid-modified morphogens of the Wnt and Hh families requires dedicated accessory proteins and may involve their packaging into lipoprotein particles for long-range transport.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.