Evidence map›Paper›PMID 19441021›Full record

SynthesisHuman brain mapping2009

Brain volume abnormalities in major depressive disorder: a meta-analysis of magnetic resonance imaging studies.

P Cédric M P Koolschijn, Neeltje E M van Haren, Gerty J L M Lensvelt-Mulders, Hilleke E Hulshoff Pol, René S Kahn

Registry-linked trialAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Human brain mapping, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01805479 (Exercise Training in Depressed Traumatic Brain Injury Survivors), which is not on this map. Cited by 375 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
375citing papers in PubMed, 18 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01805479 nawithdrawnnot on this mapstarted 2013, after this paper: background citation

Exercise Training in Depressed Traumatic Brain Injury Survivors

TypeinterventionalSponsorVirginia Commonwealth UniversityRan2013 to 2014Enrolled0ConditionsDepression, Traumatic Brain InjuryArmsaerobic exercise, stretching and flexibility program
3 · Its place in the literature

Who cites it

375 citing papers in PubMed, 18 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Pooled it
  16. Pooled it
  17. Pooled it
  18. Pooled it
  19. Trial
  20. Trial

315 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

P Cédric M P KoolschijnDepartment of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands. p.c.m.p.koolschijn@umcutrecht.nl
Neeltje E M van Haren
Gerty J L M Lensvelt-Mulders
Hilleke E Hulshoff Pol
René S Kahn

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveSo far, there have been no attempts to integrate the growing number of all brain volumetric magnetic resonance imaging studies in depression. In this comprehensive meta-analysis the magnitude and extent of brain volume differences between 2,418 patients with major depressive disorder and 1,974 healthy individuals from 64 studies was determined.

methodsA systematic research was conducted for volumetric magnetic resonance imaging studies of patients with major depressive disorder in relation to healthy control subjects. Studies had to report sufficient data for computation of effect sizes. For each study, the Cohen's d was calculated. All analyses were performed using the random effects model. Additionally, meta-regression analyses were done to explore the effects of potential sources of heterogeneity.

resultsPatients showed large volume reductions in frontal regions, especially in the anterior cingulate and orbitofrontal cortex with smaller reductions in the prefrontal cortex. The hippocampus, the putamen and caudate nucleus showed moderate volume reductions.

conclusionsThis is the first comprehensive meta-analysis in major depressive disorder demonstrating structural brain abnormalities, particularly in those brain areas that are involved in emotion processing and stress-regulation.

Indexed as

Brain MappingMagnetic Resonance ImagingBrainDatabases, BibliographicHumansImage Processing, Computer-AssistedMajor Depressive Disorder

Identifiers

PMID19441021
PMCPMC6871089

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.