ArticleEuropean radiology2009
Incomplete hippocampal inversion-is there a relation to epilepsy?
Article in European radiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Neurodevelopmental origins of self-limiting rolandic epilepsy: Systematic review of MR imaging studies.Epilepsia open · 2021Pooled it
- Neural correlates of transient topographical disorientation: an experimental EEG-MRI case study.Journal of neurology · 2023Article
- Hippocampal rotation is associated with ventricular atrial size.Pediatric radiology · 2023Article
- Temporo-basal sulcal connections: a manual annotation protocol and an investigation of sexual dimorphism and heritability.Brain structure & function · 2023Article
- Incomplete hippocampal inversion in patients with mutations in genes involved in sonic hedgehog signaling.Heliyon · 2023Article
- High Incidence of Hippocampal Abnormalities in Pediatric Patients with Congenital Cytomegalovirus Infection.Neuropediatrics · 2022Article
- Structural and Functional Deviations of the Hippocampus in Schizophrenia and Schizophrenia Animal Models.International journal of molecular sciences · 2022Review
- Hippocampal Malrotation Could Be Less Significant in Epilepsy Caused by Focal Cortical Dysplasia Type I and Type II.Frontiers in neurology · 2022Article
- Incomplete hippocampal inversion in schizophrenia: prevalence, severity, and impact on hippocampal structure.Molecular psychiatry · 2021Article
- Hippocampal Malrotation: A Genetic Developmental Anomaly Related to Epilepsy?Brain sciences · 2021Review
- Deviations in early hippocampus development contribute to visual hallucinations in schizophrenia.Translational psychiatry · 2020Article
- Article
- Subtle Brain Developmental Abnormalities in the Pathogenesis of Juvenile Myoclonic Epilepsy.Frontiers in cellular neuroscience · 2019Review
- "Unforgettable" - a pictorial essay on anatomy and pathology of the hippocampus.Insights into imaging · 2017Review
- Hippocampal volume predicts antidepressant efficacy in depressed patients without incomplete hippocampal inversion.NeuroImage. Clinical · 2016Article
- Hippocampal Malrotation Is Associated With Prolonged Febrile Seizures: Results of the FEBSTAT Study.AJR. American journal of roentgenology · 2015Article
- Incomplete Hippocampal Inversion: A Comprehensive MRI Study of Over 2000 Subjects.Frontiers in neuroanatomy · 2015Article
- Volumetric analysis of medial temporal lobe subregions in developmental amnesia using high-resolution magnetic resonance imaging.Hippocampus · 2013Article
- Hippocampal body changes in pure partial onset sleep and pure partial onset waking epileptic patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2013Article
- Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Incomplete hippocampal inversion (IHI) has been described in patients with epilepsy or severe midline malformations but also in nonepileptic subjects without obvious developmental anomalies. We studied the frequency of IHI in different epilepsy syndromes to evaluate their relationship. Three hundred patients were drawn from the regional epilepsy register. Of these, 99 were excluded because of a disease or condition affecting the temporal lobes or incomplete data. Controls were 150 subjects without epilepsy or obvious intracranial developmental anomalies. The coronal MR images were analysed without knowledge of the clinical data. Among epilepsy patients, 30% had IHI (40 left-sided, 4 right-sided, 16 bilateral). Of controls, 18% had IHI (20 left-sided, 8 bilateral). The difference was statistically significant (P < 0.05). Of temporal lobe epilepsy (TLE) patients, 25% had IHI, which was not a significantly higher frequency than in controls (P = 0.34). There was no correlation between EEG and IHI laterality. A total of 44% of Rolandic epilepsy patients and 57% of cryptogenic generalised epilepsy patients had IHI. The IHI frequency was very high in some epileptic syndromes, but not significantly higher in TLE compared to controls. No causality between TLE and IHI could be found. IHI can be a sign of disturbed cerebral development affecting other parts of the brain, maybe leading to epilepsy.
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