ArticleCurrent genomics2008
Simulation of genomes: a review.
Article in Current genomics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
- Human ancestries simulation and inference: a review of ancestral recombination graph-based approaches.Frontiers in bioinformatics · 2026Review
- Population size rescaling significantly biases outcomes of forward-in-time population genetic simulations.Genetics · 2025Article
- Accuracy of Genomic Predictions Cross Populations with Different Linkage Disequilibrium Patterns.Genes · 2024Article
- Population size rescaling significantly biases outcomes of forward-in-time population genetic simulations.bioRxiv : the preprint server for biology · 2024Article
- Potential persistence mechanisms of the major Anopheles gambiae species complex malaria vectors in sub-Saharan Africa: a narrative review.Malaria journal · 2023Review
- Demes: a standard format for demographic models.Genetics · 2022Article
- Optimal population size to detect quantitative trait loci in Korean native chicken: a simulation study.Animal bioscience · 2022Article
- Efficient ancestry and mutation simulation with msprime 1.0.Genetics · 2022Article
- Accuracy of Genomic Selection for Important Economic Traits of Cashmere and Meat Goats Assessed by Simulation Study.Frontiers in veterinary science · 2022Article
- AdmixSim 2: a forward-time simulator for modeling complex population admixture.BMC bioinformatics · 2021Article
- Zombi: a phylogenetic simulator of trees, genomes and sequences that accounts for dead linages.Bioinformatics (Oxford, England) · 2020Article
- PGsim: A Comprehensive and Highly Customizable Personal Genome Simulator.Frontiers in bioengineering and biotechnology · 2020Article
- Sampling strategy optimization to increase statistical power in landscape genomics: A simulation-based approach.Molecular ecology resources · 2020Article
- Theoretical Evaluation of Multi-Breed Genomic Prediction in Chinese Indigenous Cattle.Animals : an open access journal from MDPI · 2019Article
- Expected benefit of genomic selection over forward selection in conifer breeding and deployment.PloS one · 2018Article
- Molecular Population Genetics.Genetics · 2017Review
- Article
- skelesim: an extensible, general framework for population genetic simulation in R.Molecular ecology resources · 2017Article
- Efficient Coalescent Simulation and Genealogical Analysis for Large Sample Sizes.PLoS computational biology · 2016Article
- Approaching Long Genomic Regions and Large Recombination Rates with msParSm as an Alternative to MaCS.Evolutionary bioinformatics online · 2016Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is an increasing role of population genetics in human genetic research linking empirical observations with hypotheses about sequence variation due to historical and evolutionary causes. In addition, the data sets are increasing in size, with genome-wide data becoming a common place in many empirical studies. As far as more information is available, it becomes clear that simplest hypotheses are not consistent with data. Simulations will provide the key tool to contrast complex hypotheses on real data by generating simulated data under the hypothetical historical and evolutionary conditions that we want to contrast. Undoubtedly, developing tools for simulating large sequences that at the same time allow simulate natural selection, recombination and complex demography patterns will be of great interest in order to better understanding the trace left on the DNA by different interacting evolutionary forces. Simulation tools will be also essential to evaluate the sampling properties of any statistics used on genome-wide association studies and to compare performance of methods applied at genome-wide scales. Several recent simulation tools have been developed. Here, we review some of the currently existing simulators which allow for efficient simulation of large sequences on complex evolutionary scenarios. In addition, we will point out future directions in this field which are already a key part of the current research in evolutionary biology and it seems that it will be a primary tool in the future research of genome and post-genomic biology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.