ArticleCurrent genomics2008
On the epistemological crisis in genomics.
Article in Current genomics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- High-Dimensional Statistical Learning: Roots, Justifications, and Potential Machineries.Cancer informatics · 2015Review
- Untangling statistical and biological models to understand network inference: the need for a genomics network ontology.Frontiers in genetics · 2014Article
- On the impoverishment of scientific education.EURASIP journal on bioinformatics & systems biology · 2013Article
- Scientific knowledge is possible with small-sample classification.EURASIP journal on bioinformatics & systems biology · 2013Article
- On Kolmogorov Asymptotics of Estimators of the Misclassification Error Rate in Linear Discriminant Analysis.Sankhya. Series A. (2008) · 2013Article
- Antidotes, antibody-mediated immunity and the future of pharmaceutical product development.Human vaccines & immunotherapeutics · 2013Review
- On the limitations of biological knowledge.Current genomics · 2012Article
- Reverse engineering biomolecular systems using -omic data: challenges, progress and opportunities.Briefings in bioinformatics · 2012Article
- The illusion of distribution-free small-sample classification in genomics.Current genomics · 2011Article
- Multiple-rule bias in the comparison of classification rules.Bioinformatics (Oxford, England) · 2011Article
- Performance of feature selection methods.Current genomics · 2009Article
- Translational science: epistemology and the investigative process.Current genomics · 2009Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
There is an epistemological crisis in genomics. At issue is what constitutes scientific knowledge in genomic science, or systems biology in general. Does this crisis require a new perspective on knowledge heretofore absent from science or is it merely a matter of interpreting new scientific developments in an existing epistemological framework? This paper discusses the manner in which the experimental method, as developed and understood over recent centuries, leads naturally to a scientific epistemology grounded in an experimental-mathematical duality. It places genomics into this epistemological framework and examines the current situation in genomics. Meaning and the constitution of scientific knowledge are key concerns for genomics, and the nature of the epistemological crisis in genomics depends on how these are understood.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.