ArticleInternational journal of environmental research and public health2009
Maternal smoking, GSTM1 and GSTT1 polymorphism and susceptibility to adverse pregnancy outcomes.
Article in International journal of environmental research and public health, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 4 of them syntheses that pooled it.
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Who cites it
50 citing papers in PubMed, 4 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- Association between prenatal environmental tobacco smoke exposure and preterm birth: A systematic review and meta-analysis.Acta obstetricia et gynecologica Scandinavica · 2025Pooled it
- A meta-analysis of epigenome-wide association studies of ultra-processed food consumption with DNA methylation in European children.Clinical epigenetics · 2025Pooled it
- Household polluting cooking fuels and adverse birth outcomes: An updated systematic review and meta-analysis.Frontiers in public health · 2023Pooled it
- The Urban Exposome during Pregnancy and Its Socioeconomic Determinants.Environmental health perspectives · 2018Pooled it
- Update of the human early life exposome (HELIX) cohort: a European population-based exposome cohort-cohort profile.BMJ open · 2026Article
- Chemical exposome patterns in mothers and children across urbanisation levels in five European birth cohorts.Journal of exposure science & environmental epidemiology · 2026Article
- Association of pre-and postnatal mercury exposure with cardiometabolic risk factors in children: the role of the telomere length and telomerase reverse transcriptase polymorphisms.Environment international · 2025Article
- Outdoor air pollution, road traffic noise, and allostatic load in children aged 6-11 years: evidence from six European cohorts.European journal of epidemiology · 2025Article
- The multi-omics signatures of telomere length in childhood.BMC genomics · 2025Article
- Prenatal Exposure to Chemical Mixtures and Metabolic Syndrome Risk in Children.JAMA network open · 2024Article
- Epimutation detection in the clinical context: guidelines and a use case from a new Bioconductor package.Epigenetics · 2023Article
- Blood miRNA levels associated with ADHD traits in children across six European birth cohorts.BMC psychiatry · 2023Article
- Polymorphisms in Glutathione S-Transferase (Genes · 2023Article
- Environmental exposures in early-life and general health in childhood.Environmental health : a global access science source · 2023Article
- Article
- Multi-omics signatures of the human early life exposome.Nature communications · 2022Article
- Association of Prenatal Exposure to Endocrine-Disrupting Chemicals With Liver Injury in Children.JAMA network open · 2022Article
- Identification of autosomal cis expression quantitative trait methylation (cis eQTMs) in children's blood.eLife · 2022Article
- Urinary metabolic biomarkers of diet quality in European children are associated with metabolic health.eLife · 2022Article
- Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of the study was to investigate the association between maternal smoking, GSTM1, GSTT1 polymorphism, low birth weight (LBW, < 2,500 g) and intra-uterine growth restriction (IUGR, < 2,500 g and gestation > or = 37 weeks) risk. Within a prospective cohort study in Kaunas (Lithuania), a nested case-control study on LBW and IUGR occurrence among 646 women with genotyping of GSTT1 and GSTM1 polymorphisms who delivered live singletons was conducted. Multivariate logistic regression analysis was used to study the association of maternal smoking and polymorphism in two genes metabolizing xenobiotics. Without consideration of genotype, light-smoking (mean 4.8 cigarettes/day) during pregnancy was associated with a small increase in LBW risk, adjusted OR 1.21; 95% CI 0.44-3.31. The corresponding odds for IUGR risk was 1.57; 95% CI 0.45-5.55. The findings suggested the greater LBW risk among light-smoking mothers with the GSTM1-null genotype (OR 1.91; 95% CI 0.43-8.47) compared to those with GSTM1-present genotype (OR 1.11; 95% CI 0.26-4.47). When both GSTM1 and GSTT1 genotypes were considered, the synergistic effect was found among smoking mothers: GSTT1-present and GSTM1-null genotype OR for LBW was 3.31; 95% CI 0.60-18.4 and that for IUGR was 2.47; 95% CI 0.31-13.1. However there was no statistically significant interaction between maternal smoking, GSTT1- present and GSTM1-null genotypes for LBW (OR 1.45; 95% CI 0.22-10.1, p = 0.66) and for IUGR (OR 1.10; 95% CI 0.10-12.6, p = 0.93). The results of this study suggested that smoking, even at a low-level, ought to be considered a potential risk factor for adverse birth outcomes and that genetic polymorphism may contribute to individual variation in tobacco smoke response.
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