ArticlePloS one2009
Discovery of mating in the major African livestock pathogen Trypanosoma congolense.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- The Relevance of the Predominant Clonal Evolution (PCE) Model for the Molecular Epidemiology and Subspecific Taxonomy ofPathogens (Basel, Switzerland) · 2025Review
- Experimental genetic crosses in tsetse flies of the livestock pathogen Trypanosoma congolense savannah.Parasites & vectors · 2024Article
- Pathogenicity and virulence of African trypanosomes: From laboratory models to clinically relevant hosts.Virulence · 2023Review
- Development of the livestock pathogen Trypanosoma (Nannomonas) simiae in the tsetse fly with description of putative sexual stages from the proboscis.Parasites & vectors · 2023Article
- Vivaxin genes encode highly immunogenic, non-variant antigens on the Trypanosoma vivax cell-surface.PLoS neglected tropical diseases · 2022Article
- Paving the Way: Contributions of Big Data to Apicomplexan and Kinetoplastid Research.Frontiers in cellular and infection microbiology · 2022Review
- Salivarian Trypanosomes Have Adopted Intricate Host-Pathogen Interaction Mechanisms That Ensure Survival in Plain Sight of the Adaptive Immune System.Pathogens (Basel, Switzerland) · 2021Review
- Genetic Diversity of African Trypanosomes in Tsetse Flies and Cattle From the Kafue Ecosystem.Frontiers in veterinary science · 2021Article
- Genetic diversity of trypanosome species in tsetse flies (Glossina spp.) in Nigeria.Parasites & vectors · 2019Article
- Variant antigen repertoires inGenome research · 2018Article
- Salivarian Trypanosomosis: A Review of Parasites Involved, Their Global Distribution and Their Interaction With the Innate and Adaptive Mammalian Host Immune System.Frontiers in immunology · 2018Review
- Differential virulence and tsetse fly transmissibility ofThe Onderstepoort journal of veterinary research · 2017Article
- Genetic structure of Trypanosoma congolense "forest type" circulating in domestic animals and tsetse flies in the South-West region of Cameroon.Parasite (Paris, France) · 2017Article
- An Overview ofFrontiers in microbiology · 2016Review
- Evidence and importance of genetic exchange among field populations of Trypanosoma cruzi.Acta tropica · 2015Article
- Population Genetics and Reproductive Strategies of African Trypanosomes: Revisiting Available Published Data.PLoS neglected tropical diseases · 2015Review
- Population genetics of forest type of Trypanosoma congolense circulating in Glossina palpalis palpalis of Fontem in the South-West region of Cameroon.Parasites & vectors · 2014Article
- Null allele, allelic dropouts or rare sex detection in clonal organisms: simulations and application to real data sets of pathogenic microbes.Parasites & vectors · 2014Article
- Microsatellite analysis supports clonal propagation and reduced divergence of Trypanosoma vivax from asymptomatic to fatally infected livestock in South America compared to West Africa.Parasites & vectors · 2014Article
- Population genetics of Trypanosoma brucei rhodesiense: clonality and diversity within and between foci.PLoS neglected tropical diseases · 2013Article
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Authors and funding
10 authors.
Funding
Abstract
The protozoan parasite, Trypanosoma congolense, is one of the most economically important pathogens of livestock in Africa and, through its impact on cattle health and productivity, has a significant effect on human health and well being. Despite the importance of this parasite our knowledge of some of the fundamental biological processes is limited. For example, it is unknown whether mating takes place. In this paper we have taken a population genetics based approach to address this question. The availability of genome sequence of the parasite allowed us to identify polymorphic microsatellite markers, which were used to genotype T. congolense isolates from livestock in a discrete geographical area of The Gambia. The data showed a high level of diversity with a large number of distinct genotypes, but a deficit in heterozygotes. Further analysis identified cryptic genetic subdivision into four sub-populations. In one of these, parasite genotypic diversity could only be explained by the occurrence of frequent mating in T. congolense. These data are completely inconsistent with previous suggestions that the parasite expands asexually in the absence of mating. The discovery of mating in this species of trypanosome has significant consequences for the spread of critical traits, such as drug resistance, as well as for fundamental aspects of the biology and epidemiology of this neglected but economically important pathogen.
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