ArticleGenes and immunity2009
Evaluation of C1q genomic region in minority racial groups of lupus.
Article in Genes and immunity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Review
- Association of Immune-Related Genetic and Epigenetic Alterations with Lupus Nephritis.Kidney diseases (Basel, Switzerland) · 2022Review
- Association of C1q gene cluster variants with rheumatoid arthritis: a pilot study.Rheumatology international · 2022Article
- Identifying effective diagnostic biomarkers and immune infiltration features in chronic kidney disease by bioinformatics and validation.Frontiers in pharmacology · 2022Article
- A regulatory variant in the C1Q gene cluster is associated with tuberculosis susceptibility and C1qA plasma levels in a South African population.Immunogenetics · 2020Article
- Review
- Investigation of C1-complex regions reveals new C1Q variants associated with protection from systemic lupus erythematosus, and affect its transcript abundance.Scientific reports · 2018Article
- Human and Murine Evidence for Mechanisms Driving Autoimmune Photosensitivity.Frontiers in immunology · 2018Review
- Article
- I too, am America: a review of research on systemic lupus erythematosus in African-Americans.Lupus science & medicine · 2016Review
- C1q rs292001 polymorphism and C1q antibodies in juvenile lupus and their relation to lupus nephritis.Clinical and experimental immunology · 2015Article
- Systemic lupus erythematosus diagnostics in the 'omics' era.International journal of clinical rheumatology · 2013Article
- Genetic variants in the region of the C1q genes are associated with rheumatoid arthritis.Clinical and experimental immunology · 2013Article
- Article
- Three decades of progress in treating childhood-onset lupus nephritis.Clinical journal of the American Society of Nephrology : CJASN · 2011Article
- The lupus family registry and repository.Rheumatology (Oxford, England) · 2011Article
- Genetic susceptibility to systemic lupus erythematosus in the genomic era.Nature reviews. Rheumatology · 2010Review
- Assessing association of common variation in the C1Q gene cluster with systemic lupus erythematosus.Clinical and experimental immunology · 2010Article
- Pathways: Strategies for susceptibility genes in SLE.Autoimmunity reviews · 2010Review
- The non-muscle Myosin heavy chain 9 gene (MYH9) is not associated with lupus nephritis in African Americans.American journal of nephrology · 2010Article
Corrections and comments
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Authors and funding
16 authors at 7 institutions in 1 country.
Funding
Abstract
Complement cascade plasma proteins play a complex role in the etiopathogenesis of systemic lupus erythematosus (SLE). Hereditary C1q deficiency has been strongly related to SLE; however, there are very few published SLE studies that evaluate the polymorphisms of genes encoding for C1q (A, B and C). In this study, we evaluated 17 single nucleotide polymorphisms (SNPs) across 37 kb of C1QA, C1QB and C1QC in a lupus cohort of individuals of the African-American and Hispanic origin. In a case-only analysis, a significant association at multiple SNPs in the C1QA gene was detected in African Americans with kidney nephritis (best P=4.91 x 10(-6)). In addition, C1QA was associated with SLE in African Americans with a lack of nephritis and accompanying photosensitivity when compared with that in normal controls (P=6.80 x 10(-6)). A similar trend was observed in the Hispanic subjects (P=0.003). Quantitative analysis showed that some SNPs in C1q genes might be correlated with C3 complement levels in an additive model among African Americans (best P=0.0001). The C1QA gene is associated with subphenotypes of lupus in the African-American and Hispanic subjects. Further studies with higher SNP densities in this region and other complement components are necessary to elucidate the complex genetics and phenotypic interactions between complement components and SLE.
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