ArticleJournal of neurophysiology2009
Glycine site of NMDA receptor serves as a spatiotemporal detector of synaptic activity patterns.
Article in Journal of neurophysiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- Neuroprotective effects of glycine against cisplatin-induced cognitive decline in mice.Annals of medicine and surgery (2012) · 2026Article
- New advances in small molecule drugs targeting NMDA receptors.Acta pharmacologica Sinica · 2026Review
- D-Serine's Journey Between Stars and Synapses.Neurochemical research · 2025Review
- Differential Astrocyte-Supplied NMDAR Co-Agonist for CA1 Versus Dentate Gyrus Long-Term Potentiation.Hippocampus · 2025Article
- Regional contributions of D-serine to Alzheimer's disease pathology in maleFrontiers in aging neuroscience · 2023Article
- NMDARs, Coincidence Detectors of Astrocytic and Neuronal Activities.International journal of molecular sciences · 2021Review
- Postsynaptic Serine Racemase Regulates NMDA Receptor Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Modulation of Brain Hyperexcitability: Potential New Therapeutic Approaches in Alzheimer's Disease.International journal of molecular sciences · 2020Review
- Phosphomimetic Mutation of Glycine Transporter GlyT1 C-Terminal PDZ Binding Motif Inhibits its Interactions with PSD95.Journal of molecular neuroscience : MN · 2020Article
- Metabolic modulation of neuronal gamma-band oscillations.Pflugers Archiv : European journal of physiology · 2018Article
- Gliotransmission and adenosinergic modulation: insights from mammalian spinal motor networks.Journal of neurophysiology · 2017Review
- Differential regulation of NMDA receptors by d-serine and glycine in mammalian spinal locomotor networks.Journal of neurophysiology · 2017Article
- Lrp4 in astrocytes modulates glutamatergic transmission.Nature neuroscience · 2016Article
- Glycine induces bidirectional modifications in N-methyl-D-aspartate receptor-mediated synaptic responses in hippocampal CA1 neurons.The Journal of biological chemistry · 2014Article
- Allostery in Ca²⁺ channel modulation by calcium-binding proteins.Nature chemical biology · 2014Article
- The role of D-serine and glycine as co-agonists of NMDA receptors in motor neuron degeneration and amyotrophic lateral sclerosis (ALS).Frontiers in synaptic neuroscience · 2014Review
- Multiple risk pathways for schizophrenia converge in serine racemase knockout mice, a mouse model of NMDA receptor hypofunction.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Identity of endogenous NMDAR glycine site agonist in amygdala is determined by synaptic activity level.Nature communications · 2013Article
- AMPA receptor-dependent, light-evoked D-serine release acts on retinal ganglion cell NMDA receptors.Journal of neurophysiology · 2012Article
- Cell selective conditional null mutations of serine racemase demonstrate a predominate localization in cortical glutamatergic neurons.Cellular and molecular neurobiology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium influx associated with the opening of N-methyl-D-aspartate (NMDA) receptor channels is the major signal triggering synaptic and developmental plasticity. Controlling the NMDA receptor function is therefore critical for many functions of the brain. We explored the mechanisms of synaptic activation of the NMDAR glycine site by endogenous coagonist using whole cell voltage-clamp recordings from hippocampal neurons in mixed cultures, containing both neurons and glial cells, and, under more physiological conditions, in hippocampal slices. Here we show that the glycine site of the NMDA receptor at hippocampal synapses, both in culture and acute brain slices, is not saturated by the ambient coagonist concentration and is modulated through activity-dependent coagonist release. Augmentation of the NMDA receptor-mediated synaptic responses by local glutamate-induced coagonist release is spatially restricted and determined by spatiotemporal summation of synaptic events at neighboring synaptic inputs on a single dendritic branch. Therefore different spatiotemporal patterns of presynaptic activity could be translated into different levels of the NMDAR activation in specific afferent projections. These results suggest that the NMDA receptor glycine site may serve as a detector of the spatiotemporal characteristics of presynaptic activity patterns.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.