ArticleDevelopment (Cambridge, England)2009
Interplay between activin and Hox genes determines the formation of the kidney morphogenetic field.
Article in Development (Cambridge, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- Unraveling the origin of the vertebrate kidney: Emergence from a somitic compartment.Science advances · 2026Article
- Three-dimensional culture in a bioengineered matrix and somatic cell complementation to improve growth and survival of bovine preantral follicles.Journal of assisted reproduction and genetics · 2025Article
- Shared features in ear and kidney development - implications for oto-renal syndromes.Disease models & mechanisms · 2024Article
- Article
- Clinically and biologically relevant subgroups of Wilms tumour defined by genomic and epigenomic analyses.British journal of cancer · 2021Article
- Advances in understanding vertebrate nephrogenesis.Tissue barriers · 2020Article
- Cellular and Molecular Mechanisms of Kidney Development: From the Embryo to the Kidney Organoid.Frontiers in cell and developmental biology · 2020Review
- Article
- The yin and yang of kidney development and Wilms' tumors.Genes & development · 2015Review
- Gene regulatory network of renal primordium development.Pediatric nephrology (Berlin, Germany) · 2014Review
- Kidney regeneration: common themes from the embryo to the adult.Pediatric nephrology (Berlin, Germany) · 2014Review
- The genetics and epigenetics of kidney development.Seminars in nephrology · 2013Review
- A role for Vg1/Nodal signaling in specification of the intermediate mesoderm.Development (Cambridge, England) · 2013Article
- Evo-Devo of the Human Vertebral Column: On Homeotic Transformations, Pathologies and Prenatal Selection.Evolutionary biology · 2012Article
- Analysis of nephric duct specification in the avian embryo.Development (Cambridge, England) · 2012Article
- Six2 and Wnt regulate self-renewal and commitment of nephron progenitors through shared gene regulatory networks.Developmental cell · 2012Article
- Retinoid and TGF-β families: crosstalk in development, neoplasia, immunity, and tissue repair.Seminars in nephrology · 2012Review
- Hox genes and kidney development.Pediatric nephrology (Berlin, Germany) · 2011Review
- Chromatin-based mechanisms of renal epithelial differentiation.Journal of the American Society of Nephrology : JASN · 2011Review
- Spatio-temporal regulation of Wnt and retinoic acid signaling by tbx16/spadetail during zebrafish mesoderm differentiation.BMC genomics · 2010Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The kidney develops in a specific position along the anterior-posterior axis. All vertebrate kidney tissues are derived from the intermediate mesoderm (IM), and early kidney genes such as Lim1 and Pax2 are expressed in amniotes posterior to the sixth somite axial level. IM cells anterior to this level do not express kidney genes owing to changes in their competence to respond to kidney-inductive signals present along the entire axis. We aimed to understand the molecular mechanisms governing the loss of competence of anterior IM cells and the formation of the anterior border of the kidney morphogenetic field. We identified the dorsal neural tube as the potential kidney-inductive tissue and showed that activin, a secreted morphogen, is necessary but insufficient for Lim1 induction and establishment of the kidney field. Activin or activin-like and BMP signaling cascades are activated along the entire axis, including in anterior non-kidney IM, suggesting that competence to respond to these signals involves downstream or other components. Detailed expression pattern analysis of Hox genes during early chick development revealed that paralogous group four genes share the same anterior border as the kidney genes. Ectopic expression of Hoxb4 in anterior non-kidney IM, either by retinoic acid (RA) administration or plasmid-mediated overexpression, resulted in ectopic kidney gene expression. The anterior expansion of Lim1 expression was restrained when Hoxb4 was co-expressed with a truncated form of activin receptor. We suggest a model in which the competence of IM cells to respond to TGFbeta signaling and express kidney genes is driven by RA and mediated by Hoxb4.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.