ArticleThe Journal of biological chemistry2009
Cardiotrophin-1 maintains the undifferentiated state in skeletal myoblasts.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Skeletal Muscle Regeneration in Cardiotoxin-Induced Muscle Injury Models.International journal of molecular sciences · 2022Review
- Maintenance of the Undifferentiated State in Myogenic Progenitor Cells by TGFβ Signaling is Smad Independent and Requires MEK Activation.International journal of molecular sciences · 2020Article
- Noggin inactivation affects the number and differentiation potential of muscle progenitor cells in vivo.Scientific reports · 2016Article
- The MEK-Inhibitor Selumetinib Attenuates Tumor Growth and Reduces IL-6 Expression but Does Not Protect against Muscle Wasting in Lewis Lung Cancer Cachexia.Frontiers in physiology · 2016Article
- Mega roles of microRNAs in regulation of skeletal muscle health and disease.Frontiers in physiology · 2014Review
- SHP-1 arrests mouse early embryo development through downregulation of Nanog by dephosphorylation of STAT3.PloS one · 2014Article
- Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword?The FEBS journal · 2013Review
- Flt3L is a novel regulator of skeletal myogenesis.Journal of cell science · 2013Article
- Signal-dependent fra-2 regulation in skeletal muscle reserve and satellite cells.Cell death & disease · 2013Article
- JAK-STAT pathway and myogenic differentiation.JAK-STAT · 2013Review
- Delivery of adiponectin gene to skeletal muscle using ultrasound targeted microbubbles improves insulin sensitivity and whole body glucose homeostasis.American journal of physiology. Endocrinology and metabolism · 2013Article
- An anti-inflammatory role for leukemia inhibitory factor receptor signaling in regenerating skeletal muscle.Histochemistry and cell biology · 2013Article
- RNAi screen reveals potentially novel roles of cytokines in myoblast differentiation.PloS one · 2013Article
- Impaired skeletal muscle regeneration in the absence of fibrosis during hibernation in 13-lined ground squirrels.PloS one · 2012Article
- Oncostatin M inhibits myoblast differentiation and regulates muscle regeneration.Cell research · 2011Article
- A method for the direct identification of differentiating muscle cells by a fluorescent mitochondrial dye.PloS one · 2011Article
- Muscle wasting and impaired myogenesis in tumor bearing mice are prevented by ERK inhibition.PloS one · 2010Article
- The adipokine leptin increases skeletal muscle mass and significantly alters skeletal muscle miRNA expression profile in aged mice.Biochemical and biophysical research communications · 2010Article
- Nuclear function of Smad7 promotes myogenesis.Molecular and cellular biology · 2010Article
- A new role for satellite cells: control of reinnervation after muscle injury by semaphorin 3A. Focus on "Possible implication of satellite cells in regenerative motoneuritogenesis: HGF upregulates neural chemorepellent Sema3A during myogenic differentiation".American journal of physiology. Cell physiology · 2009Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skeletal myogenesis is potently regulated by the extracellular milieu of growth factors and cytokines. We observed that cardiotrophin-1 (CT-1), a member of the interleukin-6 (IL-6) family of cytokines, is a potent regulator of skeletal muscle differentiation. The normal up-regulation of myogenic marker genes, myosin heavy chain (MyHC), myogenic regulatory factors (MRFs), and myocyte enhancer factor 2s (MEF2s) were inhibited by CT-1 treatment. CT-1 also represses myogenin (MyoG) promoter activation. CT-1 activated two signaling pathways: signal transducer and activator of transcription 3 (STAT3), and mitogen-activated protein kinase kinase (MEK), a component of the extracellular signal-regulated MAPK (ERK) pathway. In view of the known connection between CT-1 and STAT3 activation, we surprisingly found that pharmacological blockade of STAT3 activity had no effect on the inhibition of myogenesis by CT-1 suggesting that STAT3 signaling is dispensable for myogenic repression. Conversely, MEK inhibition potently reversed the inhibition of myotube formation and attenuated the repression of MRF transcriptional activity mediated by CT-1. Taken together, these data indicate that CT-1 represses skeletal myogenesis through interference with MRF activity by activation of MEK/ERK signaling. In agreement with these in vitro observations, exogenous systemic expression of CT-1 mediated by adenoviral vector delivery increased the number of myonuclei in normal post-natal mouse skeletal muscle and also delayed skeletal muscle regeneration induced by cardiotoxin injection. The expression pattern of CT-1 in embryonic and post-natal skeletal muscle and in vivo effects of CT-1 on myogenesis implicate CT-1 in the maintenance of the undifferentiated state in muscle progenitor cells.
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