ArticleNeurobiology of learning and memory2009
Metabotropic glutamate receptor 5 in conditioned taste aversion learning.
Article in Neurobiology of learning and memory, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Context and topography determine the role of basolateral amygdala metabotropic glutamate receptor 5 in appetitive Pavlovian responding.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Defining circuit-specific roles for G protein-coupled receptors in aversive learning.Current opinion in behavioral sciences · 2019Article
- Estradiol enhances the acquisition of lithium chloride-induced conditioned taste aversion in castrated male rats.Die Naturwissenschaften · 2015Article
- Ceftriaxone attenuates acquisition and facilitates extinction of cocaine-induced suppression of saccharin intake in C57BL/6J mice.Physiology & behavior · 2015Article
- The metabotropic glutamate receptor 5 role on motor behavior involves specific neural substrates.Molecular brain · 2015Article
- The metabotropic glutamate receptor, mGlu5, is required for extinction learning that occurs in the absence of a context change.Hippocampus · 2015Article
- Peripherally administered oxytocin modulates latent inhibition in a manner consistent with antipsychotic drugs.Behavioural brain research · 2015Article
- Acquisition and expression of conditioned taste aversion differentially affects extracellular signal regulated kinase and glutamate receptor phosphorylation in rat prefrontal cortex and nucleus accumbens.Frontiers in behavioral neuroscience · 2014Article
- Role of mGluR5 neurotransmission in reinstated cocaine-seeking.Addiction biology · 2013Article
- Common cellular and molecular mechanisms in obesity and drug addiction.Nature reviews. Neuroscience · 2011Review
- Molecular mechanisms underlying memory consolidation of taste information in the cortex.Frontiers in behavioral neuroscience · 2011Article
- Functional interaction of mGlu5 and NMDA receptors in aversive learning in rats.Neurobiology of learning and memory · 2011Article
- Metabotropic glutamate receptor subtype 5 antagonism in learning and memory.European journal of pharmacology · 2010Review
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Authors and funding
5 authors.
Funding
Abstract
In conditioned taste aversion (CTA), animals learn to avoid a flavored solution (conditioned stimulus, CS) previously paired with internal malaise (unconditioned stimulus, US). Metabotropic glutamate receptor 5 (mGlu5) has been implicated in learning and memory processes and is necessary for CTA. In the present study, local microinjections of a mGlu5-selective antagonist, 3-[2-methyl-1,3-thiazol-4yl)ethynyl]pyridine (MTEP, 0, 1 or 5 microg) into the insular cortex and basolateral amygdala were used in male, Sprague-Dawley rats to examine the role of mGlu5 receptors in the encoding of taste memory. MTEP was infused 20 min before saccharin intake during CTA conditioning. MTEP injection into the basolateral amygdala resulted in robust CTA, similar to the vehicle-treated animals but slowed extinction; that is, MTEP enhanced CTA. MTEP injection into the insular cortex resulted in an increased saccharin intake on the conditioning trial, which potentially influenced the performance on the test trials; MTEP had no effect on CTA learning when controlled access to saccharin was used on the conditioning trial. These results indicate that mGlu5 receptors are involved in taste memories in a region-specific manner.
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