ArticleJournal of cellular and molecular medicine2009
Oxygen-conserving reflexes of the brain: the current molecular knowledge.
Article in Journal of cellular and molecular medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 45 citations in OpenAlex.
- Central Noradrenergic Agonists in the Treatment of Ischemic Stroke-an Overview.Translational stroke research · 2020Review
- Adjudin-preconditioned neural stem cells enhance neuroprotection after ischemia reperfusion in mice.Stem cell research & therapy · 2017Article
- Antagonistic and Synergistic Activation of Cardiovascular Vagal and Sympathetic Motor Outflows in Trigeminal Reflexes.Frontiers in neurology · 2017Review
- Impaired Neurovisceral Integration of Cardiovascular Modulation Contributes to Multiple Sclerosis Morbidities.Molecular neurobiology · 2017Review
- Editorial: The Trigeminocardiac Reflex: Beyond the Diving Reflex.Frontiers in neuroscience · 2017Article
- Sleep Disorders: Is the Trigemino-Cardiac Reflex a Missing Link?Frontiers in neurology · 2017Review
- Cerebral oxidative metabolism is decreased with extreme apnoea in humans; impact of hypercapnia.The Journal of physiology · 2016Article
- Sudden Infant Death Syndrome - Role of Trigeminocardiac Reflex: A Review.Frontiers in neurology · 2016Review
- Observational
- Changes in the loading conditions induced by vagal stimulation modify the myocardial infarct size through sympathetic-parasympathetic interactions.Pflugers Archiv : European journal of physiology · 2015Article
- The trigeminocardiac reflex - a comparison with the diving reflex in humans.Archives of medical science : AMS · 2015Article
- Trigeminal cardiac reflex: new thinking model about the definition based on a literature review.Medicine · 2015Review
- Coronary spasm in neurosurgical patients and role of trigeminocardiac reflex.Neurology research international · 2014Review
- The trigemino-cardiac reflex: a view to the future.Archives of medical science : AMS · 2010Article
- Ischemic tolerance in stroke treatment.Expert review of cardiovascular therapy · 2009Review
- Stem cell transplantation in brain tumors: a new field for molecular imaging?Molecular medicine (Cambridge, Mass.)Review
- Oxygen-conserving implications of the trigemino-cardiac reflex in the brain: the molecular basis of neuroprotection?Molecular medicine (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The trigemino-cardiac reflex (TCR) may be classified as a sub-phenomenon in the group of the so-called 'oxygen-conserving reflexes'. Within seconds after the initiation of such a reflex, there is neither a powerful and differentiated activation of the sympathetic system with subsequent elevation in regional cerebral blood flow (CBF) with no changes in the cerebral metabolic rate of oxygen (CMRO(2)) or in the cerebral metabolic rate of glucose (CMRglc). Such an increase in regional CBF without a change of CMRO(2) or CMRglc provides the brain with oxygen rapidly and efficiently and gives substantial evidence that the TCR is an oxygen-conserving reflex. This system, which mediates reflex protection projects via currently undefined pathways from the rostral ventrolateral medulla oblongata to the upper brainstem and/or thalamus which finally engage a small population of neurons in the cortex. This cortical centre appears to be dedicated to reflexively transduce a neuronal signal into cerebral vasodilatation and synchronization of electrocortical activity. Sympathetic excitation is mediated by cortical-spinal projection to spinal pre-ganglionic sympathetic neurons whereas bradycardia is mediated via projections to cardiovagal motor medullary neurons. The integrated reflex response serves to redistribute blood from viscera to brain in response to a challenge to cerebral metabolism, but seems also to initiate a preconditioning mechanism. Better and more detailed knowledge of the cascades, transmitters and molecules engaged in such endogenous (neuro) protection may provide new insights into novel therapeutic options for a range of disorders characterized by neuronal death and into cortical organization of the brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.