ArticleCephalalgia : an international journal of headache2009
C-reactive protein in migraine sufferers similar to that of non-migraineurs: the Reykjavik Study.
Article in Cephalalgia : an international journal of headache, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Migraine and mortality: a systematic review and meta-analysis.Cephalalgia : an international journal of headache · 2011Pooled it
- Effect of fasting-induced headache on calcitonin gene related peptide (CGRP) and other clinical biomarkers on the first day of Ramadan: Sub-analysis from a randomized open label clinical trial.The journal of headache and pain · 2024Trial
- The effects of a multispecies probiotic on migraine and markers of intestinal permeability-results of a randomized placebo-controlled study.European journal of clinical nutrition · 2017Trial
- Diagnostic value of combined detection of serum NLR and CRP for migraine patients in the attack stage: A prospective study.Journal of medical biochemistry · 2026Article
- Association between serum high-sensitivity C-reactive protein levels and migraine: a REFORM study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Altered immunity in migraine: a comprehensive scoping review.The journal of headache and pain · 2024Article
- Serological Biomarkers of Chronic Migraine.Current pain and headache reports · 2023Review
- Biomarkers of Migraine: An Integrated Evaluation of Preclinical and Clinical Findings.International journal of molecular sciences · 2023Review
- No change in interictal C-reactive protein levels in individuals with episodic and chronic migraine: A case-control study and literature review.Frontiers in neurology · 2022Article
- Assessing the Effect of Zinc Supplementation on the Frequency of Migraine Attack, Duration, Severity, Lipid Profile and hs-CRP in Adult Women.Clinical nutrition research · 2021Article
- Evaluation of simple inflammatory blood parameters in patients with migraine.Irish journal of medical science · 2020Article
- The impact of C-reactive protein levels on headache frequency in the HUNT study 2006-2008.BMC neurology · 2019Article
- Migraine and subclinical atherosclerosis: endothelial dysfunction biomarkers and carotid intima-media thickness: a case-control study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Article
- The serum level of inflammatory markers in chronic and episodic migraine: a case-control study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Article
- Migraine and vascular disease biomarkers: A population-based case-control study.Cephalalgia : an international journal of headache · 2018Article
- Can we define migraine patients with blood high-sensitivity C-reactive protein and galectin-3 levels in the emergency department?Archives of medical science : AMS · 2018Article
- Evaluation of carotid intima-media thickness in children with migraine: a marker of subclinical atherosclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2016Article
- The change of neutrophils/lymphocytes ratio in migraine attacks: A case-controlled study.Annals of medicine and surgery (2012) · 2016Article
- Retinol-binding protein-4 and hs-CRP levels in patients with migraine.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2015Article
- Effect of Vitamin D supplementation on symptoms and C-reactive protein in migraine patients.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2015Article
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
C-reactive protein (CRP), a marker of inflammation, has been associated with cardiovascular disease. Risk of cardiovascular disease is increased in migraineurs with aura. Results from a clinical report, case-control and a cohort study suggest that CRP is elevated in migraineurs compared with non-migraineurs. We examined the proposed association in a case-control study nested within two large population-based studies. The relationship between migraine and CRP (high-sensitivity CRP) was studied in 5906 men and women aged 55.0 +/- 8.5 years in the Reykjavik Study and 1345 men and women aged 27.7 +/- 5.5 years from the Reykjavik Study for the Young. A modified version of the International Headache Society's criteria was used to categorize people into migraineurs (two or more symptoms) or non-migraineurs. Migraineurs with visual or sensory symptoms were further defined as having migraine with aura (MA) or without aura (MO). Multivariable-adjusted CRP levels were similar in migraineurs and non-migraineurs for men (0.83 vs. 0.79 mg/l, P = 0.44) and for women (0.87 vs. 0.87 mg/l, P = 0.90). When further stratified by migraine aura and age, no differences were found between non-migraineurs, MO and MA among men. In women, CRP levels were borderline higher in those with MO compared with non-migraineurs and those with MA (1.01 mg/l vs. 0.81 and 0.75 mg/l, P = 0.08 and P = 0.08) in age group 19-34 years, but significantly lower in age group 60-81 years (0.52 mg/l vs. 1.07 and 1.01 mg/l, P = 0.007 and P = 0.03). CRP levels were not increased among migraine sufferers compared with non-migraineurs. Older women migraineurs without aura had lower CRP values than non-migraineurs and migraineurs with aura.
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