ArticleCell proliferation2009
Diffusion-limited binding explains binary dose response for local arterial and tumour drug delivery.
Article in Cell proliferation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- A Comprehensive Numerical Simulation on the Safety and Efficacy of Circular-Versus Trapezoidal-Shaped Intravascular Drug-Eluting Stents.International journal for numerical methods in biomedical engineering · 2026Article
- Advances in Functional Vascular Stents for Cardiovascular Therapy with Drug Delivery and Computational Design.Pharmaceutics · 2026Review
- Endovascular Drug Delivery.Life (Basel, Switzerland) · 2024Review
- Modeling Dual Drug Delivery from Eluting Stents: The Influence of Non-Linear Binding Competition and Non-Uniform Drug Loading.Pharmaceutical research · 2023Article
- Precision delivery of liquid therapy into the arterial wall for the treatment of peripheral arterial disease.Scientific reports · 2021Article
- Article
- 3D modelling of drug-coated balloons for the treatment of calcified superficial femoral arteries.PloS one · 2021Article
- Mathematical modelling of fluid flow and solute transport to define operating parameters forInterface focus · 2020Article
- Blockade of adrenergic β-receptor activation through local delivery of propranolol from a 3D collagen/polyvinyl alcohol/hydroxyapatite scaffold promotes bone repair in vivo.Cell proliferation · 2020Article
- Taking paclitaxel coated balloons to a higher level: Predicting coating dissolution kinetics, tissue retention and dosing dynamics.Journal of controlled release : official journal of the Controlled Release Society · 2019Article
- Calcified plaque modification alters local drug delivery in the treatment of peripheral atherosclerosis.Journal of controlled release : official journal of the Controlled Release Society · 2017Article
- Ultra-hydrophilic stent platforms promote early vascular healing and minimise late tissue response: a potential alternative to second-generation drug-eluting stents.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2017Article
- Computational Model of Drug-Coated Balloon Delivery in a Patient-Specific Arterial Vessel with Heterogeneous Tissue Composition.Cardiovascular engineering and technology · 2016Article
- Endovascular Drug Delivery and Drug Elution Systems: First Principles.Interventional cardiology clinics · 2016Review
- Modelling the Impact of Atherosclerosis on Drug Release and Distribution from Coronary Stents.Annals of biomedical engineering · 2016Review
- Sustained Efficacy and Arterial Drug Retention by a Fast Drug Eluting Cross-Linked Fatty Acid Coronary Stent Coating.Annals of biomedical engineering · 2016Article
- Degree of bioresorbable vascular scaffold expansion modulates loss of essential function.Acta biomaterialia · 2015Article
- Optimization of Drug Delivery by Drug-Eluting Stents.PloS one · 2015Article
- High concentrations of drug in target tissues following local controlled release are utilized for both drug distribution and biologic effect: an example with epicardial inotropic drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2013Article
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundLocal drug delivery has transformed medicine, yet it remains unclear how drug efficacy depends on physicochemical properties and delivery kinetics. Most therapies seek to prolong release, yet recent studies demonstrate sustained clinical benefit following local bolus endovascular delivery.
objectivesThe purpose of the current study was to examine interplay between drug dose, diffusion and binding in determining tissue penetration and effect.
methodsWe introduce a quantitative framework that balances dose, saturable binding and diffusion, and measured the specific binding parameters of drugs to target tissues.
resultsModel reduction techniques augmented by numerical simulations revealed that impact of saturable binding on drug transport and retention is determined by the magnitude of a binding potential, B(p), ratio of binding capacity to product of equilibrium dissociation constant and accessible tissue volume fraction. At low B(p) (< 1), drugs are predominantly free and transport scales linearly with concentration. At high B(p) (> 40), drug transport exhibits threshold dependence on applied surface concentration.
conclusionsIn this paradigm, drugs and antibodies with large B(p) penetrate faster and deeper into tissues when presented at high concentrations. Threshold dependence of tissue transport on applied surface concentration of paclitaxel and rapamycin may explain threshold dose dependence of in vivo biological efficacy of these drugs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.