ArticleClinical and experimental immunology2009
The Anisakis simplex Ani s 7 major allergen as an indicator of true Anisakis infections.
Article in Clinical and experimental immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 70 citations in OpenAlex.
- Anisakiasis: A Decade of Molecular and Diagnostic Advancements (2015-2026).International journal of molecular sciences · 2026Review
- Allergic Anisakiasis: An Integrated Review of Human, Animal and Cellular Evidence.Biomolecules · 2026Review
- Antibodies IgA, IgE, IgM, and IgG Reactivities Against Two Species ofClinical case reports · 2025Article
- An Assessment of the Currently Available Molecular Assay for the Diagnosis of Anisakis Sensitization.International journal of molecular sciences · 2025Article
- Anisakidae and Anisakidosis: A Public Health Perspective.Pathogens (Basel, Switzerland) · 2025Review
- Food Allergies and Parasites in Children.Foods (Basel, Switzerland) · 2023Review
- Review
- Urticaria and silent parasitism by Ascaridoidea: Component-resolved diagnosis reinforces the significance of this association.PLoS neglected tropical diseases · 2020Article
- Validation of a Commercial Loop-Mediated Isothermal Amplification (LAMP) Assay for the Rapid Detection ofFoods (Basel, Switzerland) · 2020Article
- Anisakis Sensitization in the Croatian fish processing workers: Behavioral instead of occupational risk factors?PLoS neglected tropical diseases · 2020Article
- Gene expression profiles of antigenic proteins of third stage larvae of the zoonotic nematode Anisakis pegreffii in response to temperature conditions.Parasite (Paris, France) · 2019Article
- Excretory/secretory products of anisakid nematodes: biological and pathological roles.Acta veterinaria Scandinavica · 2017Review
- Allergenic activity of Pseudoterranova decipiens (Nematoda: Anisakidae) in BALB/c mice.Parasites & vectors · 2017Article
- The Anisakis Transcriptome Provides a Resource for Fundamental and Applied Studies on Allergy-Causing Parasites.PLoS neglected tropical diseases · 2016Article
- ANISERP: a new serpin from the parasite Anisakis simplex.Parasites & vectors · 2015Article
- Allergic reactions to Anisakis found in fish.Current allergy and asthma reports · 2014Review
- Anthelmintic activities of aporphine from Nelumbo nucifera Gaertn. cv. Rosa-plena against Hymenolepis nana.International journal of molecular sciences · 2014Article
- Anti-Anisakis IgE seroprevalence in the healthy Croatian coastal population and associated risk factors.PLoS neglected tropical diseases · 2014Article
- Parametrial anisakidosis.Journal of clinical microbiology · 2013Review
- Seroprevalence of antibodies against Anisakis simplex larvae among health-examined residents in three hospitals of southern parts of Korea.The Korean journal of parasitology · 2011Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ani s 7 is currently the most important excretory/secretory (ES) Anisakis simplex allergen, as it is the only one recognized by 100% of infected patients. The allergenicity of this molecule is due mainly to the presence of a novel CX(17-25)CX(9-22)CX(8)CX(6) tandem repeat motif not seen in any previously reported protein. In this study we used this allergen as a model to investigate how ES allergens are recognized during Anisakis infections, and the usefulness of a recombinant fragment of Ani s 7 allergen (t-Ani s 7) as a marker of true Anisakis infections. The possible antigenic relationship between native Ani s 7 (nAni s 7) from Anisakis and Pseudoterranova decipens antigens was also investigated. Our results demonstrate that nAni s 7 is secreted and recognized by the immune system of rats only when the larvae are alive (i.e. during the acute phase of infection), and that this molecule is not present in, or is antigenically different from, Pseudoterranova allergens. The t-Ani s 7 polypeptide is a useful target for differentiating immunoglobulin E antibodies induced by true Anisakis infections from those induced by other antigens that may cross-react with Anisakis allergens, including P. decipiens. The results also support the hypothesis that the Ani s 7 major allergen does not participate in maintaining the antigenic stimulus during chronic infections.
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