ArticleRegenerative medicine2009
Co-culture of intestinal epithelial and stromal cells in 3D collagen-based environments.
Article in Regenerative medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 28 citations in OpenAlex.
- AnBiofabrication · 2025Article
- Emerging advances in intestinal models for in vitro preclinical research.American journal of physiology. Gastrointestinal and liver physiology · 2025Review
- Cell Surface Modification-Mediated Primary Intestinal Epithelial Cell Culture Platforms for Assessing Host-Microbiota Interactions.Biomaterials research · 2024Article
- Fibroblasts modulate epithelial cell behavior within the proliferative niche and differentiated cell zone within a human colonic crypt model.Frontiers in bioengineering and biotechnology · 2024Article
- Pituitary Remodeling Throughout Life: Are Resident Stem Cells Involved?Frontiers in endocrinology · 2020Review
- Comparison of polyglycolic acid, polycaprolactone, and collagen as scaffolds for the production of tissue engineered intestine.Journal of biomedical materials research. Part B, Applied biomaterials · 2019Article
- Comparison of conventional and advanced in vitro models in the toxicity testing of nanoparticles.Artificial cells, nanomedicine, and biotechnology · 2018Review
- Review
- Buckling of a growing tissue and the emergence of two-dimensional patterns.Mathematical biosciences · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
aimTo investigate the co-culture of established intestinal epithelial cell lines and stromal cells in a series of collagen-based environments for production of tissue-engineered intestinal epithelium for in vitro investigations. MATERIALS &
methodsIntestinal epithelial cells were co-cultured with fibroblasts on a range of supporting collagen matrices including commercially available Promogran and on collagen-based gels.
resultsEpithelial growth was achieved with one combination of vimentin-expressing stromal and cytokeratin-expressing intestinal epithelial cells grown on collagen gels supplemented with Matrigel, and held at an air-liquid interface.
conclusionsCollagen-based gels can support the co-culture of intestinal epithelial and stromal cells resulting in the growth of an epithelium that has some morphological similarity to normal intestinal tissue.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.