ArticleBiochimica et biophysica acta2009
Sp1 and Sp3 regulate transcription of the cyclin-dependent kinase 5 regulatory subunit 2 (p39) promoter in neuronal cells.
Article in Biochimica et biophysica acta, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 18 citations in OpenAlex.
- Cdk5 activation promotes Cos-7 cells transition towards neuronal-like cells.Translational neuroscience · 2023Article
- Loss in efficacy measures of tolfenamic acid in a tau knock-out model: Relevance to Alzheimer's disease.Experimental biology and medicine (Maywood, N.J.) · 2019Article
- Differential effects on neurodevelopment of FTO variants in obesity and bipolar disorder suggested by in silico prediction of functional impact: An analysis in Mexican population.Brain and behavior · 2019Article
- Mithramycin A Alleviates Cognitive Deficits and Reduces Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease.Neurochemical research · 2016Article
- Tolfenamic acid reduces tau and CDK5 levels: implications for dementia and tauopathies.Journal of neurochemistry · 2015Article
- The Cdk5 activator P39 specifically links muskelin to myosin II and regulates stress fiber formation and actin organization in lens.Experimental cell research · 2015Article
- Development of kinomic analyses to identify dysregulated signaling pathways in cells expressing cytoplasmic PrP.Virology journal · 2014Article
- Enhanced taupathy and AD-like pathology in aged primate brains decades after infantile exposure to lead (Pb).Neurotoxicology · 2013Article
- Gata4 and Sp1 regulate expression of the erythropoietin receptor in cardiomyocytes.Journal of cellular and molecular medicine · 2011Article
- Mithramycin A suppresses expression of the human melanoma-associated gene ABCB8.Molecular genetics and genomics : MGG · 2011Article
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5 authors at 1 institution in 1 country.
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Abstract
Cyclin-dependent kinase 5 (cdk5) activity is critical for development and function of the nervous system. Cdk5 activity is dependent on association with the regulators p35 and p39 whose expression is highly regulated in the developing nervous system.We have identified a small 200 bp fragment of the p39 promoter that is sufficient for cell type-specific expression in neuronal cells. Mutational analysis revealed that a cluster of predicted binding sites for Sp1, AP-1/CREB/ATF and E box-binding transcription factors is essential for full activity of the p39 promoter. Electrophoretic mobility shift assays revealed that Sp1 and Sp3 bound to sequences required for p39 promoter function and chromatin immunoprecipitation assays confirmed binding of these proteins to the endogenous p39 promoter. Furthermore, depletion of either Sp1 or Sp3 by siRNA reduced expression from the p39 promoter. Our data suggest that the ubiquitously expressed transcription factors Sp1 and Sp3 regulate transcription of the cdk5 regulator p39 in neuronal cells, possibly in cooperation with tissue-specific transcription factors.
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