ArticleWorld journal of gastroenterology2009
Feasibility of confocal endomicroscopy in the diagnosis of pediatric gastrointestinal disorders.
Article in World journal of gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 38 citations in OpenAlex.
- Paediatric gastrointestinal endoscopy in the Asian-Pacific region: Recent advances in diagnostic and therapeutic techniques.World journal of gastroenterology · 2023Review
- Advances in Pediatric Diagnostic Endoscopy: A State-of-the-Art Review.JPGN reports · 2022Review
- Quantitative Diagnosis of Atrophic Gastritis by Probe-Based Confocal Laser Endomicroscopy.BioMed research international · 2020Article
- Position paper: The potential role of optical biopsy in the study and diagnosis of environmental enteric dysfunction.Nature reviews. Gastroenterology & hepatology · 2017Review
- Software for automated classification of probe-based confocal laser endomicroscopy videos of colorectal polyps.World journal of gastroenterology · 2012Article
- Ultra high magnification endoscopy: Is seeing really believing?World journal of gastrointestinal endoscopy · 2012Article
- Diagnosis of gastric intraepithelial neoplasia by narrow-band imaging and confocal laser endomicroscopy.World journal of gastroenterology · 2012Article
- Aorta fluorescence imaging by using confocal microscopy.ISRN cardiology · 2011Article
- Confocal laser endomicroscopy in the "in vivo" histological diagnosis of the gastrointestinal tract.World journal of gastroenterology · 2009Article
- In vivo histologically equivalent evaluation of gastric mucosal topologic morphology in dogs by using confocal endomicroscopy.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the feasibility and utility of confocal laser endomicroscopy (CLE) in the description of normal gastrointestinal (GI) mucosa and in the diagnosis of GI disorders in children, in comparison to histology.
methodsForty-four patients (19 female) median age 10.9 years (range 0.7-16.6 years) with suspected or known GI pathology underwent esophago-gastro-duodenoscopy (OGD) (n = 36) and/or ileocolonoscopy (IC) (n = 31) with CLE using sodium fluorescein and acriflavine as contrast agents. Histological sections were compared with same site confocal images by two experienced pediatric and GI histopathologists and endoscopists, respectively.
resultsDuodenum and ileum were intubated in all but one patient undergoing OGD and IC. The median procedure time was 16.4 min (range 7-25 min) for OGD and 27.9 min (range 15-45 min) for IC. A total of 4798 confocal images were compared with 153 biopsies from the upper GI tract from 36 procedures, and 4661 confocal images were compared with 188 biopsies from the ileocolon from 31 procedures. Confocal images were comparable to conventional histology both in normal and in pathological conditions such as esophagitis, Helicobacter pylori gastritis, celiac disease, inflammatory bowel disease, colonic heterotopia, and graft versus host disease.
conclusionCLE offers the prospect of targeting biopsies to abnormal mucosa, thereby increasing diagnostic yield, reducing the number of biopsies, decreasing the burden on the histopathological services, and reducing costs.
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