ReviewClinical reviews in allergy & immunology2010
Defects in the leukocyte adhesion cascade.
Review in Clinical reviews in allergy & immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed.
- International clinical consensus on leukocyte adhesion deficiency-I: Modified Delphi analysis.The journal of allergy and clinical immunology. Global · 2026Article
- Rare and heterogeneous manifestations of leucocyte adhesion deficiency type 1: report of two cases with diagnostic dilemmas and novel ITGB2 mutation.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2023Article
- Correcting inborn errors of immunity: From viral mediated gene addition to gene editing.Seminars in immunology · 2023Review
- CXCR2 Antagonist RIST4721 Acts as a Potent Chemotaxis Inhibitor of Mature Neutrophils Derived from Ex Vivo-Cultured Mouse Bone Marrow.Biomedicines · 2023Article
- Preclinical safety and efficacy of lentiviral-mediated gene therapy for leukocyte adhesion deficiency type I.Molecular therapy. Methods & clinical development · 2022Article
- What is the Sugar Code?Chembiochem : a European journal of chemical biology · 2022Review
- Selectin-Mediated Signaling-Shedding Light on the Regulation of Integrin Activity in Neutrophils.Cells · 2022Review
- Histidine-Rich Glycoprotein Stimulates Human Neutrophil Phagocytosis and Prolongs Survival through CLEC1A.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- When Actin is Not Actin' Like It Should: A New Category of Distinct Primary Immunodeficiency Disorders.Journal of innate immunity · 2021Review
- Defective Neutrophil Transendothelial Migration and Lateral Motility in ARPC1B Deficiency Under Flow Conditions.Frontiers in immunology · 2021Article
- Anti-αLβ2 antibodies reveal novel endocytotic cross-modulatory functionality.British journal of pharmacology · 2020Article
- Susceptibility to infection in early life: a growing role for human genetics.Human genetics · 2020Review
- Human genetic dissection of papillomavirus-driven diseases: new insight into their pathogenesis.Human genetics · 2020Review
- Successful reconstitution of leukocyte adhesion defect after umbilical cord blood stem cell transplant.Central-European journal of immunology · 2020Article
- Clinical and Genetic Spectrum of a Large Cohort of Patients With Leukocyte Adhesion Deficiency Type 1 and 3: A Multicentric Study From India.Frontiers in immunology · 2020Article
- Recurrent Infection Due to Phagocyte Dysfunction.Indian journal of pediatrics · 2019Article
- A Comparative Review of Equine SIRS, Sepsis, and Neutrophils.Frontiers in veterinary science · 2019Review
- Palatal Ulcer in Leukocyte Adhesion Deficiency: an Unusual Occurrence.Journal of clinical immunology · 2018Article
- Brain Abscess in a Child with Leukocyte Adhesion Defect: An Unusual Association.Journal of clinical immunology · 2016Article
- Neutrophils in host defense: new insights from zebrafish.Journal of leukocyte biology · 2015Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leukocyte trafficking from bloodstream to tissue is important for the continuous surveillance for foreign antigens as well as for rapid leukocyte accumulation at sites of inflammatory response or tissue injury. Leukocyte interaction with vascular endothelial cells is a pivotal event in the inflammatory response and is mediated by several families of adhesion molecules. The crucial role of the beta(2)-integrin subfamily in leukocyte emigration was established after leukocyte adhesion deficiency (LAD) I was discovered. Patients with this disorder suffer from life-threatening bacterial infections, and in its severe form, death usually occurs in early childhood unless bone marrow transplantation is performed. The LAD II disorder clarifies the role of the selectin receptors and their fucosylated ligands. Clinically, patients with LAD II suffer not only from a less severe form of infectious episodes resembling the moderate phenotype of LAD I but also from severe psychomotor and growth retardation. LAD III emphasizes the importance of the integrin-activation phase in the adhesion cascade. All hematopoietic integrin activation processes are defective, which lead to severe infection as observed in LAD I and to marked increase tendency for bleeding problems (defective activation of beta(1), beta(2), and beta(3) integrins). The various genetic defects leading to all adhesion molecules syndrome will be discussed.
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Registered trials
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