ArticleMolecular biology reports2010
Methylenetetrahydrofolate reductase gene polymorphism in diabetes and obesity.
Article in Molecular biology reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 6 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 6 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Evidence on the causal link between homocysteine and hypertension from a meta-analysis of 40 173 individuals implementing Mendelian randomization.Journal of clinical hypertension (Greenwich, Conn.) · 2019Pooled it
- Are MTHFR C677T and MTRR A66G Polymorphisms Associated with Overweight/Obesity Risk? From a Case-Control to a Meta-Analysis of 30,327 Subjects.International journal of molecular sciences · 2015Pooled it
- Association between Genetic Variants and Diabetes Mellitus in Iranian Populations: A Systematic Review of Observational Studies.Journal of diabetes research · 2015Pooled it
- Pooled it
- Association of homocysteine with type 2 diabetes: a meta-analysis implementing Mendelian randomization approach.BMC genomics · 2013Pooled it
- Common variants of homocysteine metabolism pathway genes and risk of type 2 diabetes and related traits in Indians.Experimental diabetes research · 2012Pooled it
- The Implication of a Polymorphism in the Methylenetetrahydrofolate Reductase Gene in Homocysteine Metabolism and Related Civilisation Diseases.International journal of molecular sciences · 2023Review
- Review
- Connection between gut microbiome and the development of obesity.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Review
- Association of the MTHFR 677C>T Polymorphism with Obesity and Biochemical Variables in a Young Population of Mexico.Journal of medical biochemistry · 2019Article
- Plausible relationship between homocysteine and obesity risk viaDiabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Prevalence and Associated Factors of Overweight or Obesity and Abdominal Obesity in Iranian Population: A Population-based Study of Northwestern Iran.Iranian journal of public health · 2018Article
- Adiponectin gene variants and abdominal obesity in an Iranian population.Eating and weight disorders : EWD · 2017Article
- Associations of MTHFR C677T polymorphism with insulin resistance, results of NURSE Study (Nursing Unacquainted Related Stress Etiologies).Journal of diabetes and metabolic disorders · 2017Article
- Polymorphisms of the FTO and MTHFR genes and vascular, inflammatory and metabolic marker levels in postmenopausal women.Journal of endocrinological investigation · 2016Article
- Does the MTHFR C677T gene polymorphism indicate cardiovascular disease risk in type 2 diabetes mellitus patients?Anatolian journal of cardiology · 2015Article
- Prevalence of obesity and overweight in adults and children in Iran; a systematic review.Journal of diabetes and metabolic disorders · 2014Article
- Detection of genetic variations in coagulopathy-related genes using ramified rolling circle amplification.BioMed research international · 2014Article
- Association of genetic polymorphism of PPARγ-2, ACE, MTHFR, FABP-2 and FTO genes in risk prediction of type 2 diabetes mellitus.Journal of biomedical science · 2013Review
- Methylenetetrahydrofolate reductase gene polymorphism and risk of type 2 diabetes mellitus.PloS one · 2013Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Methylenetetrahydrofolate reductase (MTHFR) polymorphism may play an important role in the pathophysiology of obesity and diabetes accompanied by obesity due to its influence on plasma homocysteine levels. There are significant and sometimes very strong relationship between levels of homocysteine and several multi-system diseases including CHD and CVA. To examine the association between MTHFR gene C677T polymorphism in diabetes and obesity with serum homocysteine levels. A total of 682 subjects were recruited in four groups (Normal, obese, diabetic and obese and diabetics). MTHFR gene C677T polymorphism was detected using PCR-RFLP technique. Serum homocysteine levels were measured using HPLC. There was a significant increase in the mean serum homocysteine levels in subjects carrying TT genotype (34.6 +/- 26.5) compared to subjects carrying CC (15.1 +/- 8) or CT genotype (16.4 +/- 7.8) (P < 0.000). We found no significant differences for MTHFR allele and genotype frequencies between different groups. Our data have confirmed the association between serum homocysteine levels and MTHFR C677T genotype reported in other populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.