ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2010
Improvement of trochanteric bone quality in an osteoporosis model after short-term treatment with parathyroid hormone: a new mechanical test for trochanteric region of rat femur.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 28 citations in OpenAlex.
- CD274 Knockout Promotes Bone Formation and Reduces Osteoclast Activity.Calcified tissue international · 2026Article
- Effects of Combined Treatment With Selective Androgen and Estrogen Receptor Modulators Ostarine and Raloxifen on Bone Tissue In Ovariectomized Rats.Calcified tissue international · 2025Article
- Effects of ligandrol as a selective androgen receptor modulator in a rat model for osteoporosis.Journal of bone and mineral metabolism · 2023Article
- Selective Androgen Receptor Modulators Combined with Treadmill Exercise Have No Bone Benefit in Healthy Adult Rats.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Treatment of osteoporosis using a selective androgen receptor modulator ostarine in an orchiectomized rat model.Endocrine · 2023Article
- A combined treatment with selective androgen and estrogen receptor modulators prevents bone loss in orchiectomized rats.Journal of endocrinological investigation · 2022Article
- Inhibition of Lipoxygenases Showed No Benefit for the Musculoskeletal System in Estrogen Deficient Rats.Frontiers in endocrinology · 2021Article
- Evaluation of ostarine as a selective androgen receptor modulator in a rat model of postmenopausal osteoporosis.Journal of bone and mineral metabolism · 2019Article
- Effect of the lipoxygenase inhibitor baicalein on bone tissue and bone healing in ovariectomized rats.Nutrition & metabolism · 2019Article
- Comparison of parathyroid hormone and strontium ranelate in combination with whole-body vibration in a rat model of osteoporosis.Journal of bone and mineral metabolism · 2017Article
- Effects of 8-Prenylnaringenin and Whole-Body Vibration Therapy on a Rat Model of Osteopenia.Journal of nutrition and metabolism · 2016Article
- Effect of Urocortin on strength and microarchitecture of osteopenic rat femur.Journal of bone and mineral metabolism · 2015Article
- High resolution x-ray: a reliable approach for quantifying osteoporosis in a rodent model.BioResearch open access · 2014Article
- A novel device for resistance-free biomechanical testing of the metaphysis of long bones.BMC musculoskeletal disorders · 2014Article
- Efficacy and safety of echinacoside in a rat osteopenia model.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Effect of parathyroid hormone on hypogonadism induced bone loss of proximal femur of orchiectomized rat.World journal of urology · 2011Article
- Improvement of femoral bone quality after low-magnitude, high-frequency mechanical stimulation in the ovariectomized rat as an osteopenia model.Calcified tissue international · 2011Article
- The effects of parathyroid hormone applied at different regimes on the trochanteric region of the femur in ovariectomized rat model of osteoporosis.Journal of osteoporosis · 2011Article
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Authors and funding
8 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
unlabelledWe have examined the changes induced in the trochanteric region of femur of ovariectomized rat after administration of estradiol and parathyroid hormone. We have developed a reproducible biomechanical test and produced trochanteric fractures to evaluate stiffness and strength of this region in addition to histomorphometry.
introductionWe investigated the short-term effects of parathyroid hormone (PTH) and estrogen (E) on the strength of the rat trochanteric region in a new mechanical test.
methodsForty-four 3-month-old female Sprague-Dawley rats were ovariectomized and 8 weeks later treated with soy-free diet (C), daily applications of orally supplied E (0.5 mg/kg food) or subcutaneously injected PTH (0.014 mg/kg), for 5 weeks, and an additional untreated group was added as sham-operated. The femurs were examined for biomechanical and histomorphometric changes.
resultsOur new mechanical test was validated in a right-left comparison. The PTH treatment induced significantly superior biomechanical results (F (max) = 225.3 N, stiffness = 314.9 N/mm) compared to E (F (max) = 182.9 N, stiffness = 237.2 N/mm), C (F (max) = 166.03 N, stiffness = 235.56 N/mm), and sham (F (max) = 192.1 N, stiffness = 267.2 N/mm). Animals of the PTH group demonstrated a significantly improved trabecular bone structure and area (75.67%) in comparison to the E (61.04%) and C (57.18%) groups.
conclusionOur new biomechanical test is valid and produces trochanteric fracture. Our results show that the short-term antiosteoporotic effects of PTH are in the trochanteric region of ovariectomized rat superior to E.
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