ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2010
The effect of telomere length, a marker of biological aging, on bone mineral density in elderly population.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Bone aging: a paradigm of multiscale degeneration and targeted rejuvenation.Bone research · 2026Review
- Telomere length as a predictive biomarker in osteoporosis (Review).Biomedical reports · 2023Review
- Telomere length as a marker of changes in body composition and fractures-an analysis of data from the NHANES 2001-2002.Frontiers in immunology · 2023Article
- Telomere Length and Risk of Incident Fracture and Arthroplasty: Findings From UK Biobank.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- Telomeres and Age-Related Diseases.Biomedicines · 2021Review
- Can telomere length predict bone health? A review of current evidence.Bosnian journal of basic medical sciences · 2020Review
- Telomere length and telomerase activity in osteoporosis and osteoarthritis.Experimental and therapeutic medicine · 2020Review
- The age modification to leukocyte telomere length effect on bone mineral density and osteoporosis among Chinese elderly women.Journal of bone and mineral metabolism · 2019Article
- Perceived age is associated with bone status in women aged 25-93 years.Age (Dordrecht, Netherlands) · 2015Article
- Select aging biomarkers based on telomere length and chronological age to build a biological age equation.Age (Dordrecht, Netherlands) · 2014Article
- Telomere length in epidemiology: a biomarker of aging, age-related disease, both, or neither?Epidemiologic reviews · 2013Review
- Physical activity and telomere biology: exploring the link with aging-related disease prevention.Journal of aging research · 2011Article
- The pathophysiology of the aging skeleton.Current osteoporosis reports · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledTelomere length (TL), as a reflection of aging and inflammatory processes, may be associated with bone mineral density (BMD). This study examines the association between TL and BMD cross-sectionally and the rate of bone loss over a 4-year period in 1,867 Chinese elderly community living subjects. After adjusting for confounding factors, no association was observed with BMD or bone loss. The decline in BMD with aging is not reflected by corresponding changes in telomere length.
introductionBone mineral density (BMD) is influenced by the dynamics of aging, inflammatory, and bone remodeling processes. Telomere length (TL) is a reflection of the former two processes and may also be associated with bone loss.
methodsHip BMD was measured in 1,867 Chinese elderly community living subjects and the relationship between leukocyte TL measured using quantitative real-time polymerase chain reaction, and bone loss after 4 years was examined.
resultsWomen had greater bone loss than men. In women, age of menopause, menarche, estrogen treatment/replacement therapy, and history of previous fracture were also among the significant covariates. However, in multivariate analyses, TL was not associated with BMD in either sex.
conclusionsTL was not associated with either baseline BMD or bone loss over 4 years and accounted for less than 1.6% of the baseline BMD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.