ArticleInternational journal of clinical and experimental medicine2009
MAP kinase phosphatase-1, a critical negative regulator of the innate immune response.
Article in International journal of clinical and experimental medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 53 citations in OpenAlex.
- The cell with many faces: lung macrophage plasticity and function in response to environmental and pathogenic insults.Physiological reviews · 2026Review
- Article
- Deciphering the Molecular Signature of Human Hyalocytes in Relation to Other Innate Immune Cell Populations.Investigative ophthalmology & visual science · 2022Article
- MAP kinase phosphatase-1, a gatekeeper of the acute innate immune response.Life sciences · 2020Review
- Dual-specificity phosphatase (DUSP) genetic variants predict pulmonary hypertension in patients with bronchopulmonary dysplasia.Pediatric research · 2020Article
- Differential regulation of cytokine and chemokine expression by MK2 and MK3 in airway smooth muscle cells.Pulmonary pharmacology & therapeutics · 2018Article
- ERK1/2 signaling is required for the initiation but not progression of TGFβ-induced lens epithelial to mesenchymal transition (EMT).Experimental eye research · 2017Article
- Microsomal Prostaglandin E Synthase-1 Expression in Inflammatory Conditions Is Downregulated by Dexamethasone: Seminal Role of the Regulatory Phosphatase MKP-1.Frontiers in pharmacology · 2017Article
- A Screen for Key Genes and Pathways Involved in High-Quality Brush Hair in the Yangtze River Delta White Goat.PloS one · 2017Article
- Mitogen-activated protein kinase phosphatase-1 prevents lipopolysaccharide-induced apoptosis in immature rat intestinal epithelial cells.Pediatric research · 2015Article
- Vinpocetine inhibits Streptococcus pneumoniae-induced upregulation of mucin MUC5AC expression via induction of MKP-1 phosphatase in the pathogenesis of otitis media.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Expression of inhibitory regulators of innate immunity in patients with active tuberculosis.BMC infectious diseases · 2015Article
- Integrative modelling of the influence of MAPK network on cancer cell fate decision.PLoS computational biology · 2013Article
- MicroRNA-146a and RBM4 form a negative feed-forward loop that disrupts cytokine mRNA translation following TLR4 responses in human THP-1 monocytes.Immunology and cell biology · 2013Article
- Mitogen-activated protein kinase phosphatase 1 disrupts proinflammatory protein synthesis in endotoxin-adapted monocytes.Clinical and vaccine immunology : CVI · 2013Article
- p38/AP-1 pathway in lipopolysaccharide-induced inflammatory responses is negatively modulated by electrical stimulation.Mediators of inflammation · 2013Article
- Immunopharmacology of lipid A mimetics.Advances in pharmacology (San Diego, Calif.) · 2013Review
- Article
- Mitogen-activated protein kinase phosphatase-1 modulates regional effects of injurious mechanical ventilation in rodent lungs.American journal of respiratory and critical care medicine · 2012Article
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Mitogen-activated protein (MAP) kinase cascades are crucial signal transduction pathways in the regulation of the host inflammatory response to infection. MAP kinase phosphatase (MKP)-1, an archetypal member of the MKP family, plays a pivotal role in the deactivation of p38 and JNK. In vitro studies using cultured macrophages have provided compelling evidence for a central role of MKP-1 in the restraint of pro-inflammatory cytokine biosynthesis. Studies using MKP-1 knockout mice have strengthened the findings from in vitro studies and defined the critical importance of MKP-1 in the regulation of pro-inflammatory cytokine synthesis in vivo during the host response to bacterial cell wall components. Upon challenge with Toll-like receptor ligands MKP-1 knockout mice produced dramatically greater amounts of inflammatory cytokines, developed severe hypotension and multi-organ failure, and exhibited a remarkable increase in mortality. More recent investigations using intact bacteria confirmed these observations and further revealed novel functions of MKP-1 in host defense against bacterial infection. These studies demonstrate that MKP-1 is an essential feedback regulator of the innate immune response, and that it plays a critical role in preventing septic shock and multi-organ dysfunction during pathogenic infection. In this review, we will summarize the studies on the function of MKP-1 in innate immune responses and discuss the regulation of this novel protein phosphatase.
Identifiers
19436832PMC2680050W118381910What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.