ArticlePloS one2009
Characterization of MgtC, a virulence factor of Salmonella enterica Serovar Typhi.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 45 citations in OpenAlex.
- From Hue to Health: Exploring the Therapeutic Potential of Plant-Pigment-Enriched Extracts.Microorganisms · 2025Article
- Antimicrobial resistance and virulence genes of invasiveSAGE open medicine · 2023Article
- Genotypic virulence profiles and associations in Salmonella isolated from meat samples in wet markets and abattoirs of Metro Manila, Philippines.BMC microbiology · 2022Article
- Efficacy of Multivalent, Cochleate-Based Vaccine againstVaccines · 2022Article
- Genomic and Evolutionary Analysis ofFrontiers in cellular and infection microbiology · 2022Article
- Virulotyping of Salmonella enterica serovar Typhi isolates from Pakistan: Absence of complete SPI-10 in Vi negative isolates.PLoS neglected tropical diseases · 2018Article
- A protein that controls the onset of aThe EMBO journal · 2018Article
- Regulation and function of the Salmonella MgtC virulence protein.Journal of microbiology (Seoul, Korea) · 2015Review
- A Macrophage Subversion Factor Is Shared by Intracellular and Extracellular Pathogens.PLoS pathogens · 2015Article
- In-feed supplementation of trans-cinnamaldehyde reduces layer-chicken egg-borne transmission of Salmonella enterica serovar enteritidis.Applied and environmental microbiology · 2015Article
- Assessment of the requirements for magnesium transporters in Bacillus subtilis.Journal of bacteriology · 2014Article
- Draft Genome Sequence of Salmonella enterica Serovar Typhi Strain STH2370.Genome announcements · 2014Article
- Mycobacterium marinum MgtC plays a role in phagocytosis but is dispensable for intracellular multiplication.PloS one · 2014Article
- Salmonella as a vaccine delivery vehicle.Expert review of vaccines · 2013Review
- Effect of plant derived antimicrobials on Salmonella enteritidis adhesion to and invasion of primary chicken oviduct epithelial cells in vitro and virulence gene expression.International journal of molecular sciences · 2013Article
- The C-terminal domain of the virulence factor MgtC is a divergent ACT domain.Journal of bacteriology · 2012Article
- Article
- sRNAs and the virulence of Salmonella enterica serovar Typhimurium.RNA biology · 2012Review
- Infection of mice by Salmonella enterica serovar Enteritidis involves additional genes that are absent in the genome of serovar Typhimurium.Infection and immunity · 2012Article
- The B. subtilis MgtE magnesium transporter can functionally compensate TRPM7-deficiency in vertebrate B-cells.PloS one · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The MgtC is a virulence factor in Salmonella Typhimurium that is required for growth at low-Mg2+ concentrations and intramacrophage survival. This gene is codified in a conserved region of the Salmonella pathogenicity island 3 (SPI-3), and is also present in the chromosome of other Salmonella serovars. In this study we characterized the MgtC factor in S. Typhi, a human specific pathogen, by using mgtC and SPI-3 mutant strains. We found that MgtC is the most important factor codified in the SPI-3 of S. Typhi for growth in low-Mg2+ media and survival within human cells. In addition, by using reporter genes we determined that the low-Mg2+ concentration, acidic media and PhoP regulator induce mgtC expression in S. Typhi. We suggest that MgtC is the most important virulence factor codified in the SPI-3 of S. Typhi.
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