ArticleInternational journal of chronic obstructive pulmonary disease2009
Frequency and clinical relevance of human bocavirus infection in acute exacerbations of chronic obstructive pulmonary disease.
Article in International journal of chronic obstructive pulmonary disease, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- The relevance of respiratory viral infections in the exacerbations of chronic obstructive pulmonary disease—a systematic review.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2014Pooled it
- Twenty years of human bocavirus research: from an unculturable virus of unclear pathogenicity to a culturable human pathogen and gene therapy vector candidate.Clinical microbiology reviews · 2025Review
- Clinical Courses and Outcomes of Patients with Chronic Obstructive Pulmonary Disease During the COVID-19 Epidemic in Hubei, China.International journal of chronic obstructive pulmonary disease · 2020Article
- Lower Airway Virology in Health and Disease-From Invaders to Symbionts.Medicina (Kaunas, Lithuania) · 2018Review
- Analysis of viral infection and biomarkers in patients with acute exacerbation of chronic obstructive pulmonary disease.The clinical respiratory journal · 2018Article
- Bocavirus infection following paediatric liver transplantation.Pediatric transplantation · 2017Article
- Different pattern of viral infections and clinical outcomes in patient with acute exacerbation of chronic obstructive pulmonary disease and chronic obstructive pulmonary disease with pneumonia.Journal of medical virology · 2016Article
- The role of viral infections in exacerbations of chronic obstructive pulmonary disease and asthma.Therapeutic advances in respiratory disease · 2016Review
- Article
- [New and rare pneumotropic viruses].Der Pneumologe · 2013Article
- The influence of virus infections on the course of COPD.European journal of microbiology & immunology · 2012Review
- Human metapneumovirus and human bocavirus associated with respiratory infection in Apulian population.Virology · 2011Article
- New respiratory viruses and the elderly.The open respiratory medicine journal · 2011Article
- No evidence for WU polyomavirus infection in chronic obstructive pulmonary disease.Infectious agents and cancer · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHuman bocavirus (HBoV) is a recently discovered parvovirus associated with acute respiratory tract infections in children. The objective of the present study was to determine the frequency and clinical relevance of HBoV infection in adult patients with acute exacerbation of chronic obstructive pulmonary disease (AE-COPD).
methodsWe retrospectively tested 212 COPD patients, 141 (66.5%) with AE-COPD and 71 (33.5%) with stable disease, of whom nasal lavage and induced sputum had been obtained for the presence of HBoV deoxyribonucleic acid (DNA). The specificity of positive polymerase chain reaction results was confirmed by sequencing.
resultsTwo hundred two of 212 patients for whom PCR results were available both for nasal lavage and induced sputum samples were eligible for data analysis. HBoV DNA was detected in three patients (1.5%). Of those, only one patient had AE-COPD. Thus, the frequency of HBoV infection demonstrated to be low in both AE-COPD (0.8%) and stable COPD (2.9%). HBoV was found in two sputum and one nasal lavage sample in different patients, respectively. Sequencing revealed >99% sequence identity with the reference strain.
conclusionHBoV detection was infrequent. Since we detected HBoV in both upper and lower respiratory tract specimens and in AE-COPD as well as stable disease, a major role of HBoV infection in adults with AE-COPD is unlikely.
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