Trial reportDiabetes care2009
Effect of intensive insulin therapy using a closed-loop glycemic control system in hepatic resection patients: a prospective randomized clinical trial.
Trial report in Diabetes care, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Guidelines for Perioperative Care for Liver Surgery: Enhanced Recovery After Surgery (ERAS) Society Recommendations 2022.World journal of surgery · 2023Pooled it
- Sliding scale insulin for non-critically ill hospitalised adults with diabetes mellitus.The Cochrane database of systematic reviews · 2018Pooled it
- Guidelines for Perioperative Care for Liver Surgery: Enhanced Recovery After Surgery (ERAS) Society Recommendations.World journal of surgery · 2016Pooled it
- Technical challenges and clinical outcomes of using a closed-loop glycemic control system in the hospital.Journal of diabetes science and technology · 2013Trial
- Anti-inflammatory effects of perioperative intensive insulin therapy during cardiac surgery with cardiopulmonary bypass.Surgery today · 2011Trial
- Association of a novel glycemic control index, time in range, with infectious complications after pancreatectomy.Hepatobiliary surgery and nutrition · 2026Article
- Early compliance to enhanced recovery protocol as a predictor of complications after liver surgery.Updates in surgery · 2025Article
- Toward Automation: The Road Traveled and Road Ahead for Integrating Automated Insulin Delivery into Inpatient Care.Diabetes technology & therapeutics · 2025Review
- Effects of an artificial pancreas on postoperative inflammation in patients with esophageal cancer.BMC surgery · 2024Article
- Time course change of the insulin requirements during the perioperative period in hepatectomy and pancreatectomy by using an artificial pancreas STG-55.Diabetology international · 2023Article
- Two Decades of Research in Artificial Pancreas: Insights from a Bibliometric Analysis.Journal of diabetes science and technology · 2022Article
- Utility of bedside artificial pancreas for postoperative glycemic control in cardiac surgery.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2021Article
- Impact of using a perioperative artificial endocrine pancreas in pancreatic resection.Annals of gastroenterological surgery · 2020Article
- Managing hyperglycemia during the COVID-19 pandemic: Improving outcomes using new technologies in intensive care.SAGE open medicine · 2020Review
- Glucose Management Technologies for the Critically Ill.Journal of diabetes science and technology · 2019Review
- Portland Intensive Insulin Therapy During Living Donor Liver Transplantation: Association with Postreperfusion Hyperglycemia and Clinical Outcomes.Scientific reports · 2018Article
- Hypoglycemia Prevention by Algorithm Design During Intravenous Insulin Infusion.Current diabetes reports · 2018Review
- Strict blood glucose control by an artificial endocrine pancreas during hepatectomy may prevent postoperative acute kidney injury.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2017Article
- Comparison between a novel and conventional artificial pancreas for perioperative glycemic control using a closed-loop system.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2017Article
- A case of perioperative glucose control by using an artificial pancreas in a patient with glycogen storage disease.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
OBJECTIVE Intensive insulin therapy (IIT) reduces morbidity and mortality in patients in surgical intensive care units. The aim of this study is to assess the effect of IIT using a closed-loop system in hepatectomized patients. RESEARCH DESIGN AND METHODS Patients were randomly assigned to receive IIT using a closed-loop system: an artificial pancreas (AP group) or conventional insulin therapy using the sliding-scale method (SS group). RESULTS The incidence of surgical-site infection in the AP group was significantly lower than that in the SS group. The length of hospitalization required for patients in the AP group was significantly shorter than that in the SS group. CONCLUSIONS Total hospital costs for patients in the AP group were significantly lower than for patients in the SS group. IIT using a closed-loop system maintained near-normoglycemia and contributed to a reduction in the incidence of SSI and total hospital costs due to shortened hospitalization.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.