ArticleCancer research2009
NORE1A tumor suppressor candidate modulates p21CIP1 via p53.
Article in Cancer research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 65 citations in OpenAlex.
- NORE1A loss promotes MASLD/MASH.Transgenic research · 2024Article
- BRCA1 and NORE1A Form a Her2/Ras Regulated Tumor Suppressor Complex Modulating Senescence.Cancers · 2023Article
- Nore1 inhibits age-associated myeloid lineage skewing and clonal hematopoiesis but facilitates termination of emergency (stress) granulopoiesis.The Journal of biological chemistry · 2023Article
- Serum Response Factor (SRF) Drives the Transcriptional Upregulation of the MDM4 Oncogene in HCC.Cancers · 2021Article
- In silico analysis predicting effects of deleterious SNPs of human RASSF5 gene on its structure and functions.Scientific reports · 2020Article
- NORE1A directs apoptotic switch of TNF signaling through reciprocal modulation of ITCH-mediated destruction of TNFRI and BAX.Oncogene · 2020Article
- The Role and Function of Ras-association domain family in Cancer: A Review.Genes & diseases · 2019Review
- The Role of the Cyclin Dependent Kinase Inhibitor p21Cancers · 2019Review
- CDCA3 mediates p21-dependent proliferation by regulating E2F1 expression in colorectal cancer.International journal of oncology · 2018Article
- TET1 inhibits cell proliferation by inducing RASSF5 expression.Oncotarget · 2017Article
- The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.Cancer letters · 2017Review
- Nonstructural protein 5B promotes degradation of the NORE1A tumor suppressor to facilitate hepatitis C virus replication.Hepatology (Baltimore, Md.) · 2017Article
- Ras signaling through RASSF proteins.Seminars in cell & developmental biology · 2016Review
- Nore1a drives Ras to flick the P53 senescence switch.Molecular & cellular oncology · 2016Article
- NORE1A Regulates MDM2 Via β-TrCP.Cancers · 2016Article
- NORE1A induction by membrane-bound CD40L (mCD40L) contributes to CD40L-induced cell death and G1 growth arrest in p21-mediated mechanism.Cell death & disease · 2016Article
- Ras Regulates Rb via NORE1A.The Journal of biological chemistry · 2016Article
- Downregulation of CDC27 inhibits the proliferation of colorectal cancer cells via the accumulation of p21Cip1/Waf1.Cell death & disease · 2016Article
- NORE1A is a Ras senescence effector that controls the apoptotic/senescent balance of p53 via HIPK2.The Journal of cell biology · 2015Article
- RASSF5A, a candidate tumor suppressor, is epigenetically inactivated in esophageal squamous cell carcinoma.Clinical & experimental metastasis · 2015Article
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
NORE1A (RASSF5) is a proapoptotic Ras effector that is frequently inactivated by promoter methylation in human tumors. It is structurally related to the RASSF1A tumor suppressor and is itself implicated as a tumor suppressor. In the presence of activated Ras, NORE1A is a potent inducer of apoptosis. However, when expressed at lower levels in the absence of activated Ras, NORE1A seems to promote cell cycle arrest rather than apoptosis. The mechanisms underlying NORE1A action are poorly understood. We have used microarray analysis of an inducible NORE1A system to screen for physiologic signaling targets of NORE1A action. Using this approach, we have identified several potential signaling pathways modulated by NORE1A. In particular, we identify the cyclin-dependent kinase inhibitor p21(CIP1) as a target for NORE1A activation and show that it is a vital component of NORE1A-mediated growth inhibition. In primary human hepatocellular carcinomas (HCC), loss of NORE1A expression is frequent and correlates tightly with loss of p21(CIP1) expression. NORE1A down-regulation in HCC also correlates with poor prognosis, enhanced proliferation, survival, and angiogenic tumor characteristics. Experimental inactivation of NORE1A results in the loss of p21(CIP1) expression and promotes proliferation. The best characterized activator of p21(CIP1) is the p53 master tumor suppressor. Further experiments showed that NORE1A activates p21(CIP1) via promoting p53 nuclear localization. Thus, we define the molecular basis of NORE1A-mediated growth inhibition and implicate NORE1A as a potential component of the ill-defined connection between Ras and p53.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.