ArticleThe Journal of clinical endocrinology and metabolism2009
Relative growth hormone deficiency and cortisol excess are associated with increased cardiovascular risk markers in obese adolescent girls.
Article in The Journal of clinical endocrinology and metabolism, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00140842 (Neuroendocrine Modulation of Metabolic Effects in Overweight Adolescents), which is not on this map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neuroendocrine Modulation of Metabolic Effects in Overweight Adolescents
Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Metformin use in children with obesity and normal glucose tolerance--effects on cardiovascular markers and intrahepatic fat.Journal of pediatric endocrinology & metabolism : JPEM · 2012 · on this mapTrial
- Impact of BMI on peak growth hormone responses to provocative tests and therapeutic outcome in children with growth hormone deficiency.Scientific reports · 2019Observational
- Article
- Anorexia nervosa, obesity and bone metabolism.Pediatric endocrinology reviews : PER · 2013Review
- Resting IL-6 and TNF-α level in children of different weight and fitness status.Pediatric exercise science · 2013Article
- The ratio of parathyroid hormone to vitamin D is a determinant of cardiovascular risk and insulin sensitivity in adolescent girls.Metabolic syndrome and related disorders · 2013Article
- Obesity and the hypothalamic-pituitary-adrenal axis in adolescent girls.Metabolism: clinical and experimental · 2012Article
- Dyslipidaemia and undernutrition in children from impoverished areas of Maceió, state of Alagoas, Brazil.International journal of environmental research and public health · 2010Article
- Visceral fat is a negative predictor of bone density measures in obese adolescent girls.The Journal of clinical endocrinology and metabolism · 2010Article
- Adipokine profile and urinary albumin excretion in isolated growth hormone deficiency.The Journal of clinical endocrinology and metabolism · 2010Article
- Effect of body mass index on peak growth hormone response to provocative testing in children with short stature.The Journal of clinical endocrinology and metabolism · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
contextObesity in adolescents is increasingly prevalent and its impact on cardiovascular risk important to determine. Hormonal predictors of cardiovascular risk markers in obese adolescents are not known.
objectiveOur objective was to examine whether relative GH deficiency and cortisol excess are determinants of increased cardiovascular risk markers in obese teenage girls. DESIGN AND
settingA cross-sectional study was conducted at a clinical research center. STUDY
participantsThirty girls (15 obese girls and 15 normal-weight controls) 12-18 years old matched for maturity and race.
main outcome measuresInflammatory markers of cardiovascular risk including high-sensitivity C-reactive protein (hsCRP), TNF-alpha receptors 1 and 2, E-selectin, soluble intercellular adhesion molecule-1, and IL-6 were analyzed. Leptin, adiponectin, and 24-h urine free cortisol (UFC) were also measured. A GHRH-arginine stimulation test was performed.
resultsThe hsCRP levels were higher in obese girls than controls (4.63 +/- 4.81 vs. 0.67 +/- 0.72 mg/liter; P = 0.002 after log conversion), as were other markers of cardiovascular risk. Eight of the 15 obese girls but no normal-weight girl had hsCRP higher than 3 mg/liter (P = 0.002). Body mass index sd score was higher than 4.0 in 87.5% of girls with hsCRP higher than 3 mg/liter and no girls with hsCRP less than 3 mg/liter. Girls with hsCRP higher than 3 mg/liter had higher UFC and lower peak GH compared with those with hsCRP less than 3 mg/liter. Peak GH was an important negative predictor of most markers of increased cardiovascular risk. In addition to peak GH, UFC and adiponectin independently predicted hsCRP.
conclusionRelative GH deficiency and cortisol excess are significant contributors to increased levels of markers of cardiovascular risk in obese adolescent girls.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.