ArticleThe American journal of pathology2009
SV40-induced expression of calretinin protects mesothelial cells from asbestos cytotoxicity and may be a key factor contributing to mesothelioma pathogenesis.
Article in The American journal of pathology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Habit of elongate amphibole particles as a predictor of mesothelial carcinogenicity.Toxicology reports · 2025Article
- Article
- The effect of self-administered methamphetamine on GABAergic interneuron populations and functional connectivity of the nucleus accumbens and prefrontal cortex.Psychopharmacology · 2022Article
- Cytosolic CaCold Spring Harbor perspectives in biology · 2020Review
- Modulation of Calretinin Expression in Human Mesothelioma Cells Reveals the Implication of the FAK and Wnt Signaling Pathways in Conferring Chemoresistance towards Cisplatin.International journal of molecular sciences · 2019Article
- Calretinin Functions in Malignant Mesothelioma Cells Cannot Be Replaced by the Closely Related CaInternational journal of molecular sciences · 2018Article
- Calretinin promotes invasiveness and EMT in malignant mesothelioma cells involving the activation of the FAK signaling pathway.Oncotarget · 2018Article
- Regulation of calretinin in malignant mesothelioma is mediated by septin 7 binding to the CALB2 promoter.BMC cancer · 2018Article
- Absence of calretinin protein expression in malignant mesotheliomas from asbestos-exposed NF2Biomarker research · 2018Article
- Selective Sparing of Striatal Interneurons after Poly (ADP-Ribose) Polymerase 1 Inhibition in the R6/2 Mouse Model of Huntington's Disease.Frontiers in neuroanatomy · 2017Article
- Overexpression or absence of calretinin in mouse primary mesothelial cells inversely affects proliferation and cell migration.Respiratory research · 2015Article
- Calretinin: from a "simple" Ca(2+) buffer to a multifunctional protein implicated in many biological processes.Frontiers in neuroanatomy · 2014Review
- Malignant mesothelioma: development to therapy.Journal of cellular biochemistry · 2014Article
- High prevalence of serum antibodies reacting with simian virus 40 capsid protein mimotopes in patients affected by malignant pleural mesothelioma.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Data-driven information retrieval in heterogeneous collections of transcriptomics data links SIM2s to malignant pleural mesothelioma.Bioinformatics (Oxford, England) · 2012Article
- Simian virus 40 transformation, malignant mesothelioma and brain tumors.Expert review of respiratory medicine · 2011Review
- Development of an enzyme-linked immunosorbent assay for the detection of human calretinin in plasma and serum of mesothelioma patients.BMC cancer · 2010Article
- Pathophysiology and biology of peritoneal carcinomatosis.World journal of gastrointestinal oncology · 2010Article
- What's the place of immunotherapy in malignant mesothelioma treatments?Cell adhesion & migrationReview
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The calcium-binding protein calretinin has emerged as a useful marker for the identification of mesotheliomas of the epithelioid and mixed types, but its putative role in tumor development has not been addressed previously. Although exposure to asbestos fibers is considered the main cause of mesothelioma, undoubtedly, not all mesothelioma patients have a history of asbestos exposure. The question as to whether the SV40 virus is involved as a possible co-factor is still highly debated. Here we show that increased expression of SV40 early gene products in the mesothelial cell line MeT-5A induces the expression of calretinin and that elevated calretinin levels strongly correlate with increased resistance to asbestos cytotoxicity. Calretinin alone mediates a significant part of this protective effect because cells stably transfected with calretinin cDNA were clearly more resistant to the toxic effects of crocidolite than mock-transfected control cells. Down-regulation of calretinin by antisense methods restored the sensitivity to asbestos toxicity to a large degree. The protective effect observed in clones with higher calretinin expression levels could be eliminated by phosphatidylinositol 3-kinase (PI3K) inhibitors, implying an important role for the PI3K/AKT signaling (survival) pathway in mediating the protective effect. Up-regulation of calretinin, resulting from either asbestos exposure or SV40 oncoproteins, may be a common denominator that leads to increased resistance to asbestos cytotoxicity and thereby contributes to mesothelioma carcinogenesis.
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