SynthesisAnnals of the rheumatic diseases2010
Association of CD40 with rheumatoid arthritis confirmed in a large UK case-control study.
Synthesis in Annals of the rheumatic diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Associations between CCL21 gene polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis.Rheumatology international · 2017Pooled it
- Association of IL-18 promoter gene polymorphisms with rheumatoid arthritis: a meta-analysis.Molecular biology reports · 2014Pooled it
- Safety, pharmacokinetics and pharmacodynamics of single rising doses of BI 655064, an antagonistic anti-CD40 antibody in healthy subjects: a potential novel treatment for autoimmune diseases.European journal of clinical pharmacology · 2018Trial
- Similarities and differences between osteoarthritis and rheumatoid arthritis: insights from Mendelian randomization and transcriptome analysis.Journal of translational medicine · 2024Article
- Review
- Effects of Human Leukocyte Antigen DRB1 Genetic Polymorphism on Anti-Cyclic Citrullinated Peptide (ANTI-CCP) and Rheumatoid Factor (RF) Expression in Rheumatoid Arthritis (RA) Patients.International journal of molecular sciences · 2023Article
- Precision Medicine in Graves' Disease: CD40 Gene Variants Predict Clinical Response to an Anti-CD40 Monoclonal Antibody.Frontiers in endocrinology · 2021Article
- The pathogenic importance of CCL21 and CCR7 in rheumatoid arthritis.Cytokine & growth factor reviews · 2020Review
- Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility.Science (New York, N.Y.) · 2019Article
- Tumour necrosis factor gene polymorphisms in Egyptian patients with rheumatoid arthritis and their relation to disease activity and severity.Central-European journal of immunology · 2019Article
- Study of cannabinoid receptor 2 Q63R gene polymorphism in Lebanese patients with rheumatoid arthritis.Clinical rheumatology · 2018Article
- Association of CD40 Gene Polymorphisms with Susceptibility to Neuromyelitis Optica Spectrum Disorders.Molecular neurobiology · 2017Article
- Targeting the programmed cell death-1 pathway in rheumatoid arthritis.Autoimmunity reviews · 2017Review
- Essential role of CCL21 in establishment of central self-tolerance in T cells.The Journal of experimental medicine · 2017Article
- Beyond TNF: TNF superfamily cytokines as targets for the treatment of rheumatic diseases.Nature reviews. Rheumatology · 2017Review
- The Influence of Human Interindividual Variability on the Low-Dose Region of Dose-Response Curve Induced by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in Primary B Cells.Toxicological sciences : an official journal of the Society of Toxicology · 2016Article
- Decreased severity of experimental autoimmune arthritis in peptidylarginine deiminase type 4 knockout mice.BMC musculoskeletal disorders · 2016Article
- Association of CD40 polymorphisms and haplotype with risk of systemic lupus erythematosus.Rheumatology international · 2016Article
- Article
- Polymorphism of the IL-18 and CD40 genes and Liver Transplant Outcome in Iranian Patients.International journal of organ transplantation medicine · 2014Article
Corrections and comments
- Erratum issued
Authors and funding
17 authors at 9 institutions in 1 country.
Funding
Abstract
objectiveA recent meta-analysis of published genome-wide association studies (GWAS) in populations of European descent reported novel associations of markers mapping to the CD40, CCL21 and CDK6 genes with rheumatoid arthritis (RA) susceptibility while a large-scale, case-control association study in a Japanese population identified association with multiple single nucleotide polymorphisms (SNPs) in the CD244 gene. The aim of the current study was to validate these potential RA susceptibility markers in a UK population.
methodsA total of 4 SNPs (rs4810485 in CD40, rs2812378 in CCL21, rs42041 in CDK6 and rs6682654 in CD244) were genotyped in a UK cohort comprising 3962 UK patients with RA and 3531 healthy controls using the Sequenom iPlex platform. Genotype counts in patients and controls were analysed with the chi(2) test using Stata.
resultsAssociation to the CD40 gene was robustly replicated (p=2 x 10(-4), OR 0.86, 95% CI 0.79 to 0.93) and modest evidence was found for association with the CCL21 locus (p=0.04, OR 1.08, 95% CI 1.01 to 1.16). However, there was no evidence for association of rs42041 (CDK6) and rs6682654 (CD244) with RA susceptibility in this UK population. Following a meta-analysis including the original data, association to CD40 was confirmed (p=7.8 x 10(-8), OR 0.87 (95% CI 0.83 to 0.92).
conclusionIn this large UK cohort, strong association of the CD40 gene with susceptibility to RA was found, and weaker evidence for association with RA in the CCL21 locus.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.