ArticleActa biomaterialia2009
Reverse micelle-mediated synthesis of calcium phosphate nanocarriers for controlled release of bovine serum albumin.
Article in Acta biomaterialia, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 94 citations in OpenAlex.
- Hydroxyapatite-based carriers for tumor targeting therapy.RSC advances · 2023Review
- Hydroxyapatite Nanoparticles in Drug Delivery: Physicochemistry and Applications.Pharmaceutics · 2021Review
- Article
- Recent Developments of Reverse Micellar Techniques for Lysozyme, Bovine Serum Albumin, and Bromelain Extraction.Molecular biotechnology · 2019Review
- Effects of polycaprolactone on alendronate drug release from Mg-doped hydroxyapatite coating on titanium.Materials science & engineering. C, Materials for biological applications · 2018Article
- Bioinspired Calcium Phosphate Nanoparticles Featuring as Efficient Carrier and Prompter for Macrophage Intervention in Experimental Leishmaniasis.Pharmaceutical research · 2016Article
- Phase stability and biological property evaluation of plasma sprayed hydroxyapatite coatings for orthopedic and dental applications.Acta biomaterialia · 2015Article
- On the fate of particles liberated from hydroxyapatite coatings in vivo.Irish journal of medical science · 2015Review
- Polycaprolactone-coated 3D printed tricalcium phosphate scaffolds for bone tissue engineering: in vitro alendronate release behavior and local delivery effect on in vivo osteogenesis.ACS applied materials & interfaces · 2014Article
- Tricalcium phosphate and tricalcium phosphate/polycaprolactone particulate composite for controlled release of protein.Materials science & engineering. C, Materials for biological applications · 2013Article
- Phase composition control of calcium phosphate nanoparticles for tunable drug delivery kinetics and treatment of osteomyelitis. I. Preparation and drug release.Journal of biomedical materials research. Part A · 2013Article
- Modulating protein adsorption onto hydroxyapatite particles using different amino acid treatments.Journal of the Royal Society, Interface · 2012Article
- Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: a review.Acta biomaterialia · 2012Review
- Electrically polarized biphasic calcium phosphates: adsorption and release of bovine serum albumin.Langmuir : the ACS journal of surfaces and colloids · 2010Article
- Microwave-processed nanocrystalline hydroxyapatite: simultaneous enhancement of mechanical and biological properties.Acta biomaterialia · 2010Article
- Zn- and Mg-doped hydroxyapatite nanoparticles for controlled release of protein.Langmuir : the ACS journal of surfaces and colloids · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Calcium phosphate (CaP) nanoparticles with a calcium to phosphorus (Ca:P) molar ratio of 1.5:1 were synthesized using reverse microemulsion. Ca(NO(3))(2).4H(2)O and H(3)PO(4) were used as the aqueous phase, cyclohexane as the organic phase and poly(oxyethylene)(12) nonylphenol ether (NP-12) as the surfactant. Depending on the calcination temperature between 600 and 800 degrees C, CaP nanoparticle showed different phases of calcium-deficient hydroxyapatite (CDHA) and beta-tricalcium phosphate (beta-TCP), particle size between 48 and 69 nm, and a BET specific average surface area between 73 and 57 m(2)g(-1). Bovine serum albumin (BSA) was used as a model protein to study loading and release behavior. The adsorptive property of BSA was investigated by the change in BET surface area of these nanoparticles and the pH of the suspension. At pH 7.5, the maximum amount of BSA was adsorbed onto CaP nanoparticle. The release kinetics of BSA showed a gradual time-dependent increase in pH 4.0 and 6.0 buffer solutions. However, the amount of protein released was significantly smaller at pH 7.2. The BSA release rate also varied depending on the presence of different phases of CaPs in the system, beta-TCP or CDHA. These results suggest that the BSA protein release rate can be controlled by changing the particle size, surface area and phase composition of the CaP nanocarriers.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.