ArticleJournal of biomedical informatics2009
Computing with evidence Part I: A drug-mechanism evidence taxonomy oriented toward confidence assignment.
Article in Journal of biomedical informatics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Developing a Knowledge Graph for Pharmacokinetic Natural Product-Drug Interactions.Journal of biomedical informatics · 2023Article
- Translational Knowledge Discovery Between Drug Interactions and Pharmacogenetics.Clinical pharmacology and therapeutics · 2020Review
- Automatically classifying the evidence type of drug-drug interaction research papers as a step toward computer supported evidence curation.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2020Article
- Translational Biomedical Informatics and Pharmacometrics Approaches in the Drug Interactions Research.CPT: pharmacometrics & systems pharmacology · 2018Review
- Drug-drug interaction discovery and demystification using Semantic Web technologies.Journal of the American Medical Informatics Association : JAMIA · 2017Article
- Formalizing Evidence Type Definitions for Drug-Drug Interaction Studies to Improve Evidence Base Curation.Studies in health technology and informatics · 2017Article
- Adding evidence type representation to DIDEO.CEUR workshop proceedings · 2016Article
- Extraction of pharmacokinetic evidence of drug-drug interactions from the literature.PloS one · 2015Article
- Towards a foundational representation of potential drug-drug interaction knowledge.CEUR workshop proceedings · 2014Article
- Personalized medicine: challenges and opportunities for translational bioinformatics.Personalized medicine · 2013Article
- Informatics confronts drug-drug interactions.Trends in pharmacological sciences · 2013Review
- Dynamic enhancement of drug product labels to support drug safety, efficacy, and effectiveness.Journal of biomedical semantics · 2013Article
- Feasibility of incorporating genomic knowledge into electronic medical records for pharmacogenomic clinical decision support.BMC bioinformatics · 2010Article
- Computing with evidence Part II: An evidential approach to predicting metabolic drug-drug interactions.Journal of biomedical informatics · 2009Article
- Deriving rules and assertions from pharmacogenomics knowledge resources in support of patient drug metabolism efficacy predictions.Journal of the American Medical Informatics Association : JAMIAArticle
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Authors and funding
4 authors.
Funding
Abstract
We present a new evidence taxonomy that, when combined with a set of inclusion criteria, enable drug experts to specify what their confidence in a drug mechanism assertion would be if it were supported by a specific set of evidence. We discuss our experience applying the taxonomy to representing drug-mechanism evidence for 16 active pharmaceutical ingredients including six members of the HMG-CoA-reductase inhibitor family (statins). All evidence was collected and entered into the Drug-Interaction Knowledge Base (DIKB); a system that can provide customized views of a body of drug-mechanism knowledge to users who do not agree about the inferential value of particular evidence types. We provide specific examples of how the DIKB's evidence model can flag when a particular use of evidence should be re-evaluated because its related conjectures are no longer valid. We also present the algorithm that the DIKB uses to identify patterns of evidence support that are indicative of fallacious reasoning by the evidence-base curators.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.