ReviewArthritis research & therapy2009
Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function.
Review in Arthritis research & therapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Article
- Beyond nutritional immunity: immune-stressing challenges basic paradigms of immunometabolism and immunology.Frontiers in nutrition · 2025Review
- Review
- Endothelial cells and organ function: applications and implications of understanding unique and reciprocal remodelling.The FEBS journal · 2020Review
- HIF1α-dependent glycolysis promotes macrophage functional activities in protecting against bacterial and fungal infection.Scientific reports · 2018Article
- Article
- Self-harm to preferentially harm the pathogens within: non-specific stressors in innate immunity.Proceedings. Biological sciences · 2016Review
- Parallel Aspects of the Microenvironment in Cancer and Autoimmune Disease.Mediators of inflammation · 2016Review
- Hypoxia inducible factor signaling modulates susceptibility to mycobacterial infection via a nitric oxide dependent mechanism.PLoS pathogens · 2013Article
- Macrophage-tumor cell interactions regulate the function of nitric oxide.Frontiers in physiology · 2013Article
- Hypoxia enhances the proliferative response of macrophages to CSF-1 and their pro-survival response to TNF.PloS one · 2012Article
- Functional characterization of human Cd33+ and Cd11b+ myeloid-derived suppressor cell subsets induced from peripheral blood mononuclear cells co-cultured with a diverse set of human tumor cell lines.Journal of translational medicine · 2011Article
- Molecular mechanisms regulating macrophage response to hypoxia.Frontiers in immunology · 2011Article
- Molecular alterations of the IDH1 gene in AML: a Children's Oncology Group and Southwest Oncology Group study.Leukemia · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
With little in the way of effective therapeutic strategies to target the innate immune response, a better understanding of the critical pathways regulating neutrophil and macrophage responses in inflammation is key to the development of novel therapies. Hypoxia inducible factor (HIF) was originally identified as a central transcriptional regulator of cellular responses to oxygen deprivation. However, the HIF signalling pathway now appears, in myeloid cells at least, to be a master regulator of both immune cell function and survival. As such, understanding the biology of HIF and its regulators may provide new approaches to myeloid-specific therapies that are urgently needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.