Evidence map›Paper›PMID 19435424›Full record

ReviewDNA and cell biology2009

Bacterial and host interactions of oral streptococci.

Jens Kreth, Justin Merritt, Fengxia Qi

Abstract readReview
In one paragraph

Review in DNA and cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

111 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Microbial Lectin-Targeting Mucus: A Glycobioinformatic Approach.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Insights into the enigma of oral streptococci in carcinogenesis.Microbiology and molecular biology reviews : MMBR · 2024
    Review
  18. Article
  19. Review
  20. Review

51 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Jens KrethDepartment of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, USA. jkreth@ouhsc.edu
Justin Merritt
Fengxia Qi

Funding

STREPTOCOCCUS MUTANS SUGAR TRANSPORT &BIOFILM FORMATIONP20RR018741 · NCRR · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI FERRETTI, JOSEPH J · 2003 to 2007
$9.7M
S. mutans: Its mutacin AntibioticR01DE014757 · NIDCR · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI QI, FENGXIA · 2003 to 2007
$1.6M
Interspecies Streptococcal Antagonisms in Oral BiofilmsR00DE018400 · NIDCR · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI KRETH, JENS · 2009 to 2011
$732k
NCRR NIH HHS P20-RR018741-05NIDCR NIH HHS 4R00DE018400-0309NIDCR NIH HHS DE014757-05NIDCR NIH HHS R00 DE018400
6 · The paper itself

Abstract

The oral microbial flora comprises one of the most diverse human-associated biofilms. Its development is heavily influenced by oral streptococci, which are considered the main group of early colonizers. Their initial attachment determines the composition of later colonizers in the oral biofilm and impacts the health or disease status of the host. Thus, the role of streptococci in the development of oral diseases is best described in the context of bacterial ecology, which itself is further influenced by interactions with host epithelial cells, the immune system, and salivary components. The tractability of the oral biofilm makes it an excellent model system for studies of complex, biofilm-associated polymicrobial diseases. Using this system, numerous cooperative and antagonistic bacterial interactions have been demonstrated to occur within the community and with the host. In this review, several recent identified interactions are presented.

Indexed as

EcosystemActinomycesAntibiosisBacterial AdhesionEpithelial CellsHost-Pathogen InteractionsHumansMouthPorphyromonasStreptococcus

Identifiers

PMID19435424
PMCPMC2903342

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.