ArticleJournal of the American Chemical Society2009
Fluorescence patterns from supramolecular polymer assembly and disassembly for sensing metallo- and nonmetalloproteins.
Article in Journal of the American Chemical Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 118 citations in OpenAlex.
- Structural Determinants of Stimuli-Responsiveness in Amphiphilic Macromolecular Nano-assemblies.Progress in polymer science · 2024Article
- Excimer-monomer fluorescence changes by supramolecular disassembly for protein sensing and quantification.Chemical communications (Cambridge, England) · 2021Article
- Array-Based Discriminative Optical Biosensors for Identifying Multiple Proteins in Aqueous Solution and Biofluids.Frontiers in chemistry · 2020Review
- Article
- Zwitterionic Amphiphilic Homopolymer Assemblies.Polymer chemistry · 2015Article
- Protein-triggered supramolecular disassembly: insights based on variations in ligand location in amphiphilic dendrons.Journal of the American Chemical Society · 2014Article
- Protein and enzyme gated supramolecular disassembly.Journal of the American Chemical Society · 2014Article
- Zwitterionic moieties from the Huisgen reaction: a case study with amphiphilic dendritic assemblies.Chemistry (Weinheim an der Bergstrasse, Germany) · 2013Article
- Advances in Polymer and Polymeric Nanostructures for Protein Conjugation.European polymer journal · 2013Article
- Temperature-sensitive transitions below LCST in amphiphilic dendritic assemblies: host-guest implications.Journal of the American Chemical Society · 2013Article
- Stimuli Sensitive Amphiphilic Dendrimers.New journal of chemistry = Nouveau journal de chimie · 2012Article
- Accessing lipophilic ligands in dendrimer-based amphiphilic supramolecular assemblies for protein-induced disassembly.Chemistry (Weinheim an der Bergstrasse, Germany) · 2012Article
- Array-based sensing with nanoparticles: 'chemical noses' for sensing biomolecules and cell surfaces.Current opinion in chemical biology · 2010Review
- Discrimination of complex mixtures by a colorimetric sensor array: coffee aromas.Analytical chemistry · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Critical aggregation concentration (CAC) of surfactants is lowered when polyelectrolytes act as counterions. At a concentration in between the CACs of the surfactant and the polymer-surfactant complex, protein-induced disassemblies can be achieved. This is because, when proteins competitively bind to the polyelectrolytes, the surfactants are not capable of sustaining a micelle-type assembly at this concentration. Since these amphiphilic aggregates are capable of noncovalently sequestering hydrophobic guest molecules, the protein binding induced disassembly process also results in a guest release from these assemblies. We show here that the change in fluorescence with different proteins is dependent not only on the nature of the polymer-surfactant complex, but also on the fluorescent transducer. Two processes can be responsible for the observed fluorescence change: fluorophore guest release from the hydrophobic interior of the assembly and excited state quenching due to complementary components in the analyte. The latter mechanism is especially possible with metalloproteins. We show here that an excited state quenching is possible at nanomolar concentrations of the proteins, while the disassembly based fluorescence reduction is the dominant pathway at micromolar concentrations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.