ArticleThe Journal of infectious diseases2009
HV-1-specific cytotoxic T lymphocytes and breast milk HIV-1 transmission.
Article in The Journal of infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Using viral sequence diversity to estimate time of HIV infection in infants.PLoS pathogens · 2023Article
- Improved HIV-positive infant survival is correlated with high levels of HIV-specific ADCC activity in multiple cohorts.Cell reports. Medicine · 2021Article
- Breast Milk Virome and Bacterial Microbiome Resilience in Kenyan Women Living with HIV.mSystems · 2021Article
- Impact of maternal HIV exposure, feeding status, and microbiome on infant cellular immunity.Journal of leukocyte biology · 2019Review
- HIV-exposed uninfected infants: elevated cord blood Interleukin 8 (IL-8) is significantly associated with maternal HIV infection and systemic IL-8 in a Kenyan cohort.Clinical and translational medicine · 2018Article
- Toll-like receptor 9 polymorphism is associated with increased Epstein-Barr virus and Cytomegalovirus acquisition in HIV-exposed infants.AIDS (London, England) · 2018Article
- Uptake of Home-Based Syphilis and Human Immunodeficiency Virus Testing Among Male Partners of Pregnant Women in Western Kenya.Sexually transmitted diseases · 2017Observational
- Lymphocyte subsets in HIV-exposed uninfected infants and HIV-unexposed uninfected infants.The Journal of allergy and clinical immunology · 2017Article
- Breastfeeding Is Associated with Decreased Risk of Hospitalization among HIV-Exposed, Uninfected Kenyan Infants.Journal of human lactation : official journal of International Lactation Consultant Association · 2016Article
- Viral Evolution and Cytotoxic T Cell Restricted Selection in Acute Infant HIV-1 Infection.Scientific reports · 2016Article
- Maternal plasma and breastmilk viral loads are associated with HIV-1-specific cellular immune responses among HIV-1-exposed, uninfected infants in Kenya.Clinical and experimental immunology · 2015Article
- Tuberculosis interferon-gamma responses in the breast milk of human immunodeficiency virus infected mothers.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2015Article
- In-utero infection with HIV-1 associated with suppressed lymphoproliferative responses at birth.Clinical and experimental immunology · 2014Article
- Mode of delivery and postpartum HIV-1 disease progression and mortality in a Kenyan cohort.BMC pregnancy and childbirth · 2014Article
- Natural killer cell and T-cell subset distributions and activation influence susceptibility to perinatal HIV-1 infection.AIDS (London, England) · 2014Article
- HIV-exposed uninfected children: a growing population with a vulnerable immune system?Clinical and experimental immunology · 2014Review
- The Significance of Interferon-γ in HIV-1 Pathogenesis, Therapy, and Prophylaxis.Frontiers in immunology · 2014Review
- Quantitative and qualitative differences in the T cell response to HIV in uninfected Ugandans exposed or unexposed to HIV-infected partners.Journal of virology · 2013Article
- The oral mucosa immune environment and oral transmission of HIV/SIV.Immunological reviews · 2013Review
- Adaptive HIV-specific B cell-derived humoral immune defenses of the intestinal mucosa in children exposed to HIV via breast-feeding.PloS one · 2013Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundBreast-feeding by infants exposed to human immunodeficiency virus type 1 (HIV-1) provides an opportunity to assess the role played by repeated HIV-1 exposure in eliciting HIV-1-specific immunity and in defining whether immune responses correlate with protection from infection.
methodsBreast-feeding infants born to HIV-1-seropositive women were assessed for HLA-selected HIV-1 peptide-specific cytotoxic T lymphocyte interferon (IFN)-gamma responses by means of enzyme-linked immunospot (ELISpot) assays at 1, 3, 6, 9, and 12 months of age. Responses were deemed to be positive when they reached > or = 50 HIV-1-specific sfu/1 x 10(6) peripheral blood mononuclear cells (PBMCs) and were at least twice those of negative controls.
resultsA total of 807 ELISpot assays were performed for 217 infants who remained uninfected with HIV-1 at approximately 12 months of age; 101 infants (47%) had at least 1 positive ELISpot result (median, 78-170 sfu/1 x 10(6) PBMCs). The prevalence and magnitude of responses increased with age (P = .01 and P = .007, respectively); the median log(10) value for HIV-1-specific IFN-gamma responses increased by 1.0 sfu/1 x 10(6) PBMCs/month (P < .001) between 1 and 12 months of age. Of 141 HIV-1-uninfected infants with 1-month ELISpot results, 10 (7%) acquired HIV-1 infection (0/16 with positive vs. 10/125 [8%] with negative ELISpot results; P = .6). Higher values for log(10) HIV-1-specific spot-forming units at 1 month of age were associated with a decreased risk of HIV-1 infection, adjusted for maternal HIV-1 RNA level (adjusted hazard ratio, 0.09 [95% confidence interval, 0.01-0.72]).
conclusion. Breast-feeding HIV-1-exposed uninfected infants frequently had HIV-1-specific IFN-gamma responses. Greater early HIV-1-specific IFN-gamma responses were associated with decreased HIV-1 acquisition.
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