ReviewCurrent opinion in neurology2009
Calcitonin gene-related peptide: an update on the biology.
Review in Current opinion in neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 65 citations in OpenAlex.
- Modulating CGRP Signaling: A Promising Therapeutic Avenue for Attenuating Cardiac Dysfunction in Heart Failure.Cardiovascular drugs and therapy · 2026Review
- Calcitonin Gene-Related Peptide Level in Cystic Fibrosis Patients.Life (Basel, Switzerland) · 2024Article
- Sustained Activation of CLR/RAMP Receptors by Gel-Forming Agonists.International journal of molecular sciences · 2022Article
- Shared Fate of Meningeal Mast Cells and Sensory Neurons in Migraine.Frontiers in cellular neuroscience · 2019Article
- From LBR-101 to Fremanezumab for Migraine.CNS drugs · 2018Review
- Unconventional Role of Caspase-6 in Spinal Microglia Activation and Chronic Pain.Mediators of inflammation · 2017Review
- Impact of Food Components on in vitro Calcitonin Gene-Related Peptide Secretion-A Potential Mechanism for Dietary Influence on Migraine.Nutrients · 2016Article
- Trigeminal Pain Molecules, Allodynia, and Photosensitivity Are Pharmacologically and Genetically Modulated in a Model of Traumatic Brain Injury.Journal of neurotrauma · 2016Article
- Calcitonin gene-related peptide (CGRP): a new target for migraine.Annual review of pharmacology and toxicology · 2015Review
- [Pain-relieving effect of CGRP antagonism on inflammatory pain].Schmerz (Berlin, Germany) · 2014Article
- Structure-activity relationships of the N-terminus of calcitonin gene-related peptide: key roles of alanine-5 and threonine-6 in receptor activation.British journal of pharmacology · 2014Article
- CGRP and migraine: could PACAP play a role too?Neuropeptides · 2013Review
- Selective CGRP and adrenomedullin peptide binding by tethered RAMP-calcitonin receptor-like receptor extracellular domain fusion proteins.Protein science : a publication of the Protein Society · 2013Article
- Gestational environment programs adult depression-like behavior through methylation of the calcitonin gene-related peptide gene.Molecular psychiatry · 2013Article
- The calcitonin gene-related peptide receptor antagonist MK-8825 decreases spinal trigeminal activity during nitroglycerin infusion.The journal of headache and pain · 2013Article
- Roles of CLR/RAMP receptor signaling in reproduction and development.Current protein & peptide science · 2013Review
- Lack of migraine in headaches of familial dysautonomia patients.Journal of neural transmission (Vienna, Austria : 1996) · 2013Article
- Modulation of CGRP-induced light aversion in wild-type mice by a 5-HT(1B/D) agonist.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Expression of the transient receptor potential channels TRPV1, TRPA1 and TRPM8 in mouse trigeminal primary afferent neurons innervating the dura.Molecular pain · 2012Article
- A role for the sensory neuropeptide calcitonin gene-related peptide in endothelial cell proliferation in vivo.British journal of pharmacology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewThis review includes the most relevant and recent studies on the biology of calcitonin gene-related peptide (CGRP) as it pertains to primary headaches and particularly to migraine. Especial attention was given to those published within the last year. RECENT
findingsThe development of CGRP receptor antagonists is discussed in detail, as well as recent advances in our understanding of CGRP actions in migraine. Finally, other important functions of CGRP outside of the nervous system are briefly discussed. SUMMARY: The advent of CGRP receptor antagonists as a novel therapy for migraine attacks may represent a new era in the acute management of migraine. More than a simple addition to the currently available treatments, this group of drugs may become an outstanding option for patients with cardiovascular disease, given the lack of associated vasoconstriction. Furthermore, nonpeptide CGRP receptor antagonists, CGRP antibodies and CGRP-binding RNA-Spiegelmer are valuable research tools that will further advance our understanding of migraine pathophysiology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.